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Targeted cancer immunotherapy with genetically engineered oncolytic Salmonella typhimurium.

Abstract：

:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among them. Attenuated Salmonella have very specific targeting to various solid cancers, making them ideal vectors for the delivery and expression of immunostimulators. They have native bacterial immunogenicity and induce strong anticancer immunity in vivo. In this review, the recent advances in Salmonella-mediated cancer immunotherapies and the related mechanisms of Salmonella-based cancer therapies are summarized.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Guo Y,Chen Y,Liu X,Min JJ,Tan W,Zheng JH

doi

10.1016/j.canlet.2019.10.033

subject

Has Abstract

pub_date

2020-01-28 00:00:00

pages

102-110

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(19)30536-1

journal_volume

469

pub_type

杂志文章,评审

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