Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4.

abstract：:This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 ...

journal_title：Cancer letters

authors： Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

更新日期：2004-04-15 00:00:00

abstract：:Development of drug resistance to standard chemotherapy is a common phenomenon that leads to poor prognosis in patients. Thus, novel agents that can attenuate chemoresistance are urgently needed. Therefore, we analyzed whether isorhamnetin (IH), a 3'-O-methylated metabolite of quercetin, can enhance the potential effi...

journal_title：Cancer letters

authors： Manu KA,Shanmugam MK,Ramachandran L,Li F,Siveen KS,Chinnathambi A,Zayed ME,Alharbi SA,Arfuso F,Kumar AP,Ahn KS,Sethi G

更新日期：2015-07-10 00:00:00

abstract：:Neuroblastoma (NB) is a solid childhood tumour that exhibits heterogeneous biological and clinical phenotypes. Multiple drug resistance marks a major complication especially in high-risk patients with advanced tumour stages and specific genetic aberrations, such as MYCN amplification and lp deletion. As an approach to...

journal_title：Cancer letters

authors： Paffhausen T,Schwab M,Westermann F

更新日期：2007-05-18 00:00:00

abstract：:We have used human procathepsin D isolated from supernatant of human breast cancer cell line ZR-75-1 to test its mitogenic activity for a broad spectrum of human-derived cell lines. These cell lines included: breast cancer cell lines ZR-75-1, MDA-MB-436, MBA-MD-483 and MDA-MB-231, B lymphoblastoid cell line Raji, the ...

journal_title：Cancer letters

authors： Vĕtvicka V,Vĕktvicková J,Fusek M

更新日期：1994-05-16 00:00:00

abstract：:Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...

journal_title：Cancer letters

authors： Boccardo F,Guarneri D,Zanardi S,Castellani P,Borsi L,Zardi L

更新日期：1986-12-01 00:00:00

abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

journal_title：Cancer letters

authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

更新日期：1982-05-01 00:00:00

abstract：:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...

journal_title：Cancer letters

authors： Metcalfe SA,Cain K,Hill BT

更新日期：1986-05-01 00:00:00

abstract：:The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...

journal_title：Cancer letters

authors： Brown RC,Poole A,Fleming GT

更新日期：1983-03-01 00:00:00

abstract：:Diol-epoxide derivatives of polycyclic aromatic hydrocarbons are the ultimate carcinogenic forms of these compounds encountered in vivo. Using a novel electro-fluorescence apparatus, we report that, like the (+/-)-anti-diol-epoxide of benzo[a]pyrene (BP), the similar diol-epoxides of benzo[a]anthracene (BA) and 3-meth...

journal_title：Cancer letters

authors： Ridler P,Jennings B

更新日期：1984-02-01 00:00:00

abstract：:Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...

journal_title：Cancer letters

authors： Wu MS,Wang HP,Lin CC,Sheu JC,Shun CT,Lee WJ,Lin JT

更新日期：1997-11-25 00:00:00

abstract：:The South American opossum, Monodelphis domestica, has been used as a model system to study ultraviolet (UV)-induced genetic alterations that lead to the development of melanoma. Suckling young of Monodelphis exposed to multiple doses of UVB radiation can develop benign or malignant melanomas later as adults. Point mu...

journal_title：Cancer letters

authors： Chan J,Robinson ES,Yeh IT,McCarrey JR

更新日期：2002-10-08 00:00:00

abstract：:Tumour cell attachment to the endothelial cell lining of the circulatory system is of utmost importance in the process of cancer spread. We describe here a method of quantifying tumour cell attachment to an endothelial cell layer in vitro, using the fluorescent carbocyanine dye, 1,1'-dioctadecyl-3,3,3',3'-tetramethyli...

journal_title：Cancer letters

authors： Hiscox S,Jiang WG

更新日期：1997-01-30 00:00:00

abstract：:Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-07-26 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

journal_title：Cancer letters

authors： Shen C,Yang C,Xia B,You M

更新日期：2021-03-01 00:00:00

abstract：:Substantial evidence from epidemiological studies supports the inverse association between the intake of fruits, vegetables and other plant products and cancer incidence. Cancer-preventive constituents of fruits and vegetables may inhibit carcinogen activation, enhance carcinogen detoxification, prevent carcinogens fr...

journal_title：Cancer letters

authors： Tatman D,Mo H

更新日期：2002-01-25 00:00:00

abstract：:Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoy...

journal_title：Cancer letters

authors： Colombo D,Compostella F,Ronchetti F,Scala A,Toma L,Kuchide M,Tokuda H,Nishino H

更新日期：2000-12-20 00:00:00

abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

journal_title：Cancer letters

authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

更新日期：2003-02-20 00:00:00

abstract：:The modulating effect of ethanol/acetone (E/A) soluble fractions, prepared from methanolic extracts of processed and unprocessed rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) as well as green (Camellia sinensis) teas was established in a two-stage mouse skin carcinogenesis assay. Topical applicatio...

journal_title：Cancer letters

authors： Marnewick J,Joubert E,Joseph S,Swanevelder S,Swart P,Gelderblom W

更新日期：2005-06-28 00:00:00

abstract：:The effect of a purified, high protein diet on enhanced gastric carcinogenesis induced by oral administration of NaCl was investigated in Wistar rats. Rats were fed on a purified diet with an equalized caloric content, containing 8% NaCl and 25% casein (normal protein diet), or 50% casein (high protein diet) after ora...

journal_title：Cancer letters

authors： Tatsuta M,Iishi H,Baba M,Uehara H,Nakaizumi A,Iseki K

更新日期：1997-06-24 00:00:00

abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...

journal_title：Cancer letters

authors： Kim DG,Jo BH,You KR,Ahn DS

更新日期：1996-10-01 00:00:00

abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

journal_title：Cancer letters

authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

更新日期：1984-04-01 00:00:00

abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...

journal_title：Cancer letters

authors： Xu W,Chen GS,Shao Y,Li XL,Xu HC,Zhang H,Zhu GQ,Zhou YC,He XP,Sun WH

更新日期：2013-05-10 00:00:00

abstract：:Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg ...

journal_title：Cancer letters

authors： Mitsumori K,Yasuhara K,Mori I,Hayashi S,Shimo T,Onodera H,Nomura T,Hayashi Y

更新日期：1998-07-17 00:00:00

abstract：:In order to search for the direct evidence of cellular response to low-dose radiation, we investigated wild-type p53 protein accumulation in several organs of mice after exposure to low doses of X-rays. Significant p53 accumulation within 24 h was observed in the mouse adrenal glands and pancreas after X-ray irradiati...

journal_title：Cancer letters

authors： Wang X,Matsumoto H,Takahashi A,Nakano T,Okaichi K,Ihara M,Ohnishi T

更新日期：1996-06-24 00:00:00

abstract：:Hepatitis B virus (HBV) is a major etiologic agent of hepatocellular carcinoma (HCC). However, the molecular mechanism by which HBV infection contributes to HCC development is not fully understood. Here, we initially showed that HBV stimulates the production of cancer stem cells (CSCs)-related markers (CD133, CD117 an...

journal_title：Cancer letters

authors： Liu Z,Dai X,Wang T,Zhang C,Zhang W,Zhang W,Zhang Q,Wu K,Liu F,Liu Y,Wu J

更新日期：2017-08-01 00:00:00

abstract：:Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...

journal_title：Cancer letters

authors： Büssing A,Suzart K,Bergmann J,Pfüller U,Schietzel M,Schweizer K

更新日期：1996-01-19 00:00:00

abstract：:The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated with their pattern of somatostatin receptor (sst1-sst5) expression. Recently, we demonstrated that expression of a truncated sst5-variant (sst5TMD4) can influence the secretory response of somatotropinomas to SSA-therapy; however, i...

journal_title：Cancer letters

authors： Luque RM,Ibáñez-Costa A,Neto LV,Taboada GF,Hormaechea-Agulla D,Kasuki L,Venegas-Moreno E,Moreno-Carazo A,Gálvez MÁ,Soto-Moreno A,Kineman RD,Culler MD,Gahete MD,Gadelha MR,Castaño JP

更新日期：2015-04-10 00:00:00

abstract：:A novel second generation retroviral producer cell strategy (an adenoviral/retroviral combined delivery system) has been developed by this laboratory. In the present studies, this delivery system was used to examine its delivery efficiency in vitro and in vivo by using a marker gene, LacZ, and a therapeutic gene, herp...

journal_title：Cancer letters

authors： Pan Y,Zhai P,Dashti AM,Wu S,Lin X,Wu M

更新日期：2002-10-28 00:00:00

abstract：:Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...

journal_title：Cancer letters

authors： Yokozaki H,Ito R,Ono S,Hayashi K,Tahara E

更新日期：1999-06-01 00:00:00

abstract：:Previous studies had established that transforming growth factor-beta1 (TGF-beta1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial...

journal_title：Cancer letters

authors： Lin CT,Yu MT,Li C,Ho YC,Shen CH,Liu DW,Chang DC,Wu SF

更新日期：2010-05-01 00:00:00