Abstract：
:In the presence of iron, dihydroartemisinin forms free radicals and causes cell death. Since most cancer cells have high rates of iron intake, dihydroartemisinin would have selective cytotoxic effect on cancer cells. The present experiment was designed to study the effect of dihydroartemisinin and ferrous sulfate on the growth of implanted fibrosarcoma in the rat. We found that the growth rate of the tumor was significantly retarded by daily oral administration of ferrous sulfate followed by dihydroartemisinin. No significant tumor growth retardation effect was observed in rats treated with either dihydroartemisinin or ferrous sulfate alone. The drug treatment did not significantly affect body weight compared with untreated tumor-implanted animals and no apparent toxic effect was observed after drug treatment. An artemisinin analog-ferrous salt combination may provide a novel approach for cancer therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Moore JC,Lai H,Li JR,Ren RL,McDougall JA,Singh NP,Chou CKsubject
Has Abstractpub_date
1995-11-27 00:00:00pages
83-7issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(95)90207-4journal_volume
98pub_type
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