Abstract:
:The anti-carcinogenic activity of dietary fruit and vegetables observed in several epidemiological and experimental animal studies is likely to be an effect of the combined exposure to a large number of substances acting together. This is plausible, as these compounds are present simultaneously in a diet containing vegetables and fruit. Further, some compounds have been experimentally demonstrated to modify several mechanisms involved in carcinogenesis. The effect of combined exposure is demonstrated in the present article, summarizing the effects of a complex mixture of anti-carcinogenic substances (from broccoli) on different antioxidative defense enzymes and on cytochrome P-450 activities in rat liver, kidney and colon. The responses were related to the levels of different specific glucosinolates.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Vang O,Rasmussen BF,Andersen Odoi
10.1016/s0304-3835(97)04681-8subject
Has Abstractpub_date
1997-03-19 00:00:00pages
283-6issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(97)04681-8journal_volume
114pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract::Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells. We tested the hypothesis that the oncogenic effects of PRL occur by increasing cellular proliferation. Cells stably transfected with PRL-1 or PRL-2 exhibited 2.7-3.3-fold increases over control cells in the rat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00517-2
更新日期:2003-12-30 00:00:00
abstract::The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90193-5
更新日期:1987-12-01 00:00:00
abstract::Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2009.02.016
更新日期:2009-11-01 00:00:00
abstract::Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.03.035
更新日期:2018-07-01 00:00:00
abstract::Elevated cyclooxygenase-2 (COX-2) expression has been observed in various types of cancer. Induction of COX-2 expression has been reported to increase invasiveness and angiogenesis of tumours. While COX-2 overexpression has been repeatedly proven to promote tumor growth, little is known about what initiates its induct...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.03.023
更新日期:2006-02-28 00:00:00
abstract::Tumor promoters such as phorbol esters, teleocidin and okadaic acid increase the numbers of multilayered, transformed foci produced by BPV DNA-transfected C3H/10T1/2 cells. We questioned whether arsenic and chromium, which are known human carcinogens also enhance transformation of BPV DNA-transfected C3H/10T1/2 cells....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04189-4
更新日期:1996-05-15 00:00:00
abstract::Protease inhibitors have been shown to be highly effective suppressors of carcinogenesis in both in vivo and in vitro model systems. For example, the soybean derived Bowman Birk inhibitor (BBI) has been shown to inhibit colon carcinogenesis. Although the precise mechanisms by which protease inhibitors suppress carcino...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90063-2
更新日期:1992-04-15 00:00:00
abstract::We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00491-2
更新日期:2000-10-01 00:00:00
abstract::The accumulation of benzoporphyrin derivative (BPD) in malignant and host cell populations of the mouse RIF tumor was studied by flow cytometry analysis of cells dissociated from the tumor tissue. The highest cellular BPD levels were found in a subpopulation of tumor associated macrophages (TAMs) characterized by a hi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03985-6
更新日期:1995-11-06 00:00:00
abstract::The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a.epoxy-4,5,6,6a-tetrahydroB...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04328-5
更新日期:1996-09-10 00:00:00
abstract::14-3-3 sigma is a negative regulator of the cell cycle and contributes to G2 arrest. Thus far, the lack of its expression due to hypermethylation of the CpG islands has been reported in some carcinomas. In this study, we investigated the expression of 14-3-3 sigma in thyroid neoplasms by means of immunohistochemistry ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00282-9
更新日期:2003-10-28 00:00:00
abstract::The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03836-l
更新日期:1995-07-20 00:00:00
abstract::Previously, we have shown that simian virus 40 (SV40) T antigen can directly cause apoptosis in immortalized human epithelial cells under normal growth conditions. In this study, we further characterized the mechanism of T-antigen-mediated apoptosis involving p53 and whether T antigen can suppress erbB2/neu gene expre...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00360-7
更新日期:1999-03-22 00:00:00
abstract::Methylnitrosourea (MNU)-induced carcinomas in organ-cultured human pancreas when injected into nude mice produced subcutaneous carcinomas none of which recognizable as being of acinar cell origin. Both monoclonal antibody to acinar cell surface marker produced by hybridoma, and in vitro tumor cell differentiation were...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90040-4
更新日期:1982-02-01 00:00:00
abstract::Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2007.04.015
更新日期:2007-10-08 00:00:00
abstract::lncRNAs regulate the initiation and progression of osteosarcoma, although the mechanism by which this occurs remains unknown. The present study shows that over-expression of the lncRNA DANCR increased osteosarcoma cell proliferation, migration, and invasion in vitro, as well as promoted xenograft tumor growth and lung...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.06.009
更新日期:2017-10-01 00:00:00
abstract::A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90004-1
更新日期:1984-01-01 00:00:00
abstract::Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.06.029
更新日期:2011-11-28 00:00:00
abstract::The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.11.034
更新日期:2009-05-08 00:00:00
abstract::The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90055-7
更新日期:1984-05-01 00:00:00
abstract::Specific [3H]fucose-labeled glycoproteins were found in the serum of rats bearing Zajdela hepatoma, which possess different isoelectric points in comparison with serum glycoproteins from normal rats. The electrophoretic profile of the serum glycoproteins is significantly altered. There is approximately a 2.5 times inc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00524-7
更新日期:1998-03-13 00:00:00
abstract::The guinea pig Kurloff cell (KC) is an estradiol-dependent circulating mononuclear cell that had natural killer cytotoxic activity in vitro. We studied the variation of KC number during the development of transplanted leukemia in inbred strain 2 (S2) leukemia-sensitive guinea pigs. Grafts of leukemic cells (L2C) produ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03960-5
更新日期:1995-10-20 00:00:00
abstract::Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00053-8
更新日期:2002-07-26 00:00:00
abstract::The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can adapt to chemotherapy through a positive-feedback loop that favors chemoresistance. In platinum-resistant OC cells we ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.08.026
更新日期:2020-11-01 00:00:00
abstract::Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90205-4
更新日期:1994-06-30 00:00:00
abstract::Inhibition of DNA synthesis was observed and quantitated in hamster buccal pouch epithelium exposed in vivo and in vitro to indirect acting carcinogens. Topical application of a 0.5% solution of the potent hamster buccal pouch carcinogen 7,12-dimethylbenz[a]-anthracene (DMBA) acutely inhibited epithelial DNA synthesis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90210-o
更新日期:1990-09-01 00:00:00
abstract::In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90066-3
更新日期:1988-04-01 00:00:00
abstract::Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00171-2
更新日期:1998-10-23 00:00:00
abstract::Recent studies indicate that gossypol possesses potent antitumor activities in vitro and in vivo. The nuclear factor-kappa B (NF-kappaB) plays an important role in tumor cell growth, proliferation, invasion, and survival. In this study, we investigated the effects and the molecular mechanisms of gossypol on NF-kappaB ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.01.030
更新日期:2008-06-18 00:00:00
abstract::A single administration of enantiomerically pure 11,12-dihydrodiols of dibenzo[a,l]pyrene (DB[a,l]P) on the back of NMRI mice and subsequent chronic treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) (initiation/promotion assay) revealed strikingly different carcinogenic activities of both enantiomers. Tumor-in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00265-1
更新日期:1999-03-01 00:00:00