Abstract:
:In order to examine the in vivo genotoxic activity of dichlorvos, lambdalacZ transgenic mice (Muta Mouse) were treated i.p. with single (4.4 or 11 mg/kg) or multiple (5 x 11 mg/kg) doses of this agent and sacrificed 4 h or 14 days post-treatment for DNA adduct measurement or mutant frequency analysis, respectively. Neither methylated DNA adducts nor an increase in mutant frequency were detected in the bone marrow, white blood cells, liver, spleen, lung, brain and sperm cells after the single doses. However, following multiple dosing a statistically significant 3-fold increase in mutant frequency was observed in the liver, while a non-statistically significant increase was observed in the bone marrow. In contrast, dimethylsulphate, a model methylating agent, gave rise to detectable DNA adducts but no increase in mutant frequency following i.p. administration of single (30 mg/kg) or multiple (10 x 6 mg/kg) doses.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Pletsa V,Steenwinkel MJ,van Delft JH,Baan RA,Kyrtopoulos SAdoi
10.1016/s0304-3835(99)00256-6keywords:
subject
Has Abstractpub_date
1999-11-15 00:00:00pages
155-60issue
2eissn
0304-3835issn
1872-7980pii
S0304383599002566journal_volume
146pub_type
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