Therapeutic efficiency of IL-2 gene transduced tumor vaccine for head and neck carcinoma.

abstract：:The influence of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a mutagen in chlorinated water, on cell proliferation and lipid peroxidation in the glandular stomach mucosa was investigated in male 4-week-old Wistar rats. Animals were given 50 p.p.m., 25 p.p.m., 12.5 p.p.m., 6.25 p.p.m. or 0 p.p.m. of MX soluti...

journal_title：Cancer letters

authors： Nishikawa A,Kinae N,Furukawa F,Mitsui M,Enami T,Hasegawa T,Takahashi M

更新日期：1994-10-14 00:00:00

abstract：:The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the a...

journal_title：Cancer letters

authors： Chmurzyńska W,Manteuffel-Cymborowska M,Sikora E,Grzelakowska-Sztabert B

更新日期：1984-12-01 00:00:00

abstract：:In this study we combined flow cytometry with fluorescence in situ hybridization to detect numerical aberrations in chromosomes. Fifty-nine human malignant gliomas were examined by flow cytometry for DNA-content and cell cycle analysis and for numerical aberrations of chromosome 1 by in situ hybridization using a chro...

journal_title：Cancer letters

authors： Ehemann V,Hashemi B,Lange A,Otto HF

更新日期：1999-04-26 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) tumor cells are surrounded by a protective tumor microenvironment (TME). Trabectedin, an anticancer drug targeting both tumor cells and TME, demonstrated a potent antitumor activity against Hodgkin Reed Sternberg (HRS) cells. It was cytotoxic against cHL cell lines, including the doxor...

journal_title：Cancer letters

authors： Casagrande N,Borghese C,Favero A,Vicenzetto C,Aldinucci D

更新日期：2021-03-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

journal_title：Cancer letters

authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

更新日期：2011-12-26 00:00:00

abstract：:Previously, we have shown that dietary retinoic acid (RA) at pharmacological doses (30 micrograms/g of diet) inhibited the malignant conversion of skin papillomas to carcinomas induced by a two-stage carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA)...

journal_title：Cancer letters

authors： Chen LC,Kirchhoff S,De Luca LM

更新日期：1994-04-01 00:00:00

abstract：:Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, its action mechanism is still controversial. Here, we showed that Core down-regulated levels of p16, resulting in inactivation of Rb and subsequent activation of E2F1, which lead to growth stimulation of hepatocytes. For...

journal_title：Cancer letters

authors： Park SH,Lim JS,Lim SY,Tiwari I,Jang KL

更新日期：2011-11-01 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00

abstract：:Protease inhibitors (PIs) of synthetic, bacterial or soybean origin have been shown to suppress carcinogen or radiation-induced rat mammary carcinogenesis. We report, for the first time, the effect of year-long feeding of Field bean meal, a rich source of PIs with a 24% protein content, at different protein levels in ...

journal_title：Cancer letters

authors： Fernandes AO,Banerji AP

更新日期：1997-06-03 00:00:00

abstract：:Zinc finger transcription factors are DNA-binding proteins that are known to determine the identity of cells by regulating cell-specific gene expression. In addition, mutations in some members of this family have been found to be associated with several neoplasias, including Wilms' tumor and leukemias. Because the mec...

journal_title：Cancer letters

authors： Mesa K,Gebelein B,Cook T,Urrutia R

更新日期：1996-06-05 00:00:00

abstract：:In order to characterize the enzymes involved in the purine nucleotide catabolism as indicators of invasiveness and aggressiveness of malignant gliomas, the degradation of extracellular nucleotides by five different glioma cell lines was investigated and compared with primary astrocytes. Rapid hydrolysis of extracellu...

journal_title：Cancer letters

authors： Wink MR,Lenz G,Braganhol E,Tamajusuku AS,Schwartsmann G,Sarkis JJ,Battastini AM

更新日期：2003-08-20 00:00:00

abstract：:6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...

journal_title：Cancer letters

authors： Lee SJ,Sakurai H,Koizumi K,Song GY,Bae YS,Kim HM,Kang KS,Surh YJ,Saiki I,Kim SH

更新日期：2006-02-20 00:00:00

abstract：:The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...

journal_title：Cancer letters

authors： Nagabhushan M,Line D,Polverini PJ,Solt DB

更新日期：1992-10-21 00:00:00

abstract：:The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...

journal_title：Cancer letters

authors： Lazear EJ,Louie SC

更新日期：1978-01-01 00:00:00

abstract：:We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...

journal_title：Cancer letters

authors： Marzec KA,Martino-Echarri E,Irminger-Finger I,Henderson BR

更新日期：2016-10-10 00:00:00

abstract：:Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory ...

journal_title：Cancer letters

authors： Jiang D,Chen S,Sun R,Zhang X,Wang D

更新日期：2018-04-10 00:00:00

abstract：:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

journal_title：Cancer letters

authors： Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

更新日期：2015-01-28 00:00:00

abstract：:Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...

journal_title：Cancer letters

authors： Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

更新日期：2020-05-01 00:00:00

abstract：:Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...

journal_title：Cancer letters

authors： Schwartz HS

更新日期：1983-08-01 00:00:00

abstract：:Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotox...

journal_title：Cancer letters

authors： Choy YM,Cheng CP,Luey LU,Loh SC,Fung KP,Lee CY

更新日期：1987-10-01 00:00:00

abstract：:To be capable of selective killing of tumor cells, the non-selective Pseudomonas aeruginosa exotoxin A must have its cell-binding domain inactivated or removed and then be chemically linked to, or genetically fused with, a specific targeting agent. In the present study, epsilon-NH2 groups of lysine residues of the cel...

journal_title：Cancer letters

authors： Bourdenet S,Doyonnas R,Vacheron MJ,Guinand M,Fasciotto B,Ristic A,Michel G,Cozzone AJ,Durkin JP,Whitfield JF

更新日期：1990-04-20 00:00:00

abstract：:The incidence of breast cancer has increased rapidly in recent years and has now become the most common cancer in women in major cities of China. Here, we reviewed the history and progress of breast cancer research in China, including achievements that Chinese scientists have made in basic, translational and clinical ...

journal_title：Cancer letters

authors： Hong W,Dong E

更新日期：2014-08-28 00:00:00

abstract：:The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary thyroid carcinoma (PTC) tissue. Additionally, the expression of dC...

journal_title：Cancer letters

authors： Karbownik M,Brzezianska E,Lewinski A

更新日期：2005-07-28 00:00:00

abstract：:Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...

journal_title：Cancer letters

authors： Awasthi N,Hinz S,Brekken RA,Schwarz MA,Schwarz RE

更新日期：2015-03-01 00:00:00

abstract：:The alkylation of hamster liver, lung and pancreas DNA by [1-14C]- and [2,3-14C]N-nitrosobis (2-oxopropyl) amine (BOP) has been examined. The specific activity of pancreas DNA after [2,3-14C]BOP administration was only 2% of that when [1-14C]BOP was given. 7-Methylguanine, but not O-6-methylguanine, was found in hydro...

journal_title：Cancer letters

authors： Lawson TA,Gingell R,Nagel D,Hines LA,Ross A

更新日期：1981-01-01 00:00:00

abstract：:The effects of turmeric (T), curcumins (Cs), aqueous turmeric extract (ATE) and curcumin-free aqueous turmeric extract (CFATE) on the formation of [3H]benzo[a]pyrene ([3H]B(a)P)-derived DNA adducts was studied in vitro employing mouse liver S9. A dose-dependent decrease in binding of [3H]B(a)P metabolites to calf thym...

journal_title：Cancer letters

authors： Deshpande SS,Maru GB

更新日期：1995-09-04 00:00:00

abstract：:In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

journal_title：Cancer letters

authors： Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

更新日期：2013-05-10 00:00:00

abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...

journal_title：Cancer letters

authors： Kim DG,Jo BH,You KR,Ahn DS

更新日期：1996-10-01 00:00:00

abstract：:The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...

journal_title：Cancer letters

authors： Deangelo AB,Garrett CT

更新日期：1983-09-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known ab...

journal_title：Cancer letters

authors： Sun J,Luo Q,Liu L,Song G

更新日期：2018-07-28 00:00:00