Abstract:
:The influence of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a mutagen in chlorinated water, on cell proliferation and lipid peroxidation in the glandular stomach mucosa was investigated in male 4-week-old Wistar rats. Animals were given 50 p.p.m., 25 p.p.m., 12.5 p.p.m., 6.25 p.p.m. or 0 p.p.m. of MX solution in their drinking water for 5 weeks. At the end of this period, cell proliferation in the mucosal epithelia of the gastric fundus was increased in a dose-dependent manner up to 25 p.p.m., at which dose the induction was statistically significant as compared with the control value (P < 0.05). The MX treatment was also associated with increased lipid peroxidation levels in the gastric mucosa as well as in the urine, with loose dose-dependence, although not at 50 p.p.m. Mucosal lipid peroxidation was significantly increased in animals given 25 p.p.m. as compared with controls (P < 0.05). Similarly, the levels of urinary lipid peroxidation were significantly higher in rats given 25 p.p.m. or 12.5 p.p.m. than in the controls (P < 0.05). Histopathologically, gastric erosion was noted in rats receiving 25 p.p.m. or more of MX. There were no statistical differences between groups for serum biochemical data. The results thus suggest that MX may exert a gastric tumor-promoting action in rats, even at low doses which do not give rise to toxic effects, because of the clear dose-response relationship evident at low levels.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Nishikawa A,Kinae N,Furukawa F,Mitsui M,Enami T,Hasegawa T,Takahashi Mdoi
10.1016/0304-3835(94)90268-2subject
Has Abstractpub_date
1994-10-14 00:00:00pages
151-7issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(94)90268-2journal_volume
85pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accomp...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.11.036
更新日期:2012-05-01 00:00:00
abstract::Osteosarcoma is the most common osteogenic malignant tumor characterized by a high level of malignancy, relapse, metastasis and poor prognosis. S100A4 has been implicated in the proliferation, cell cycle progression, and metastasis of many malignant tumors, although the roles of S100A4 in osteosarcoma have not been do...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.08.016
更新日期:2010-12-28 00:00:00
abstract::As a cellular degradation mechanism, autophagy exerts crucial and complicated effects on HCC development. Liver non-parenchymal cells, including hepatic resident macrophage Kupffer cells, also play important roles in this process. However, most associated studies have focused on the influence of the autophagy level in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.12.004
更新日期:2017-03-01 00:00:00
abstract::Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00185-7
更新日期:1997-06-24 00:00:00
abstract::The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90249-2
更新日期:1988-09-01 00:00:00
abstract::The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.09.013
更新日期:2005-05-26 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.05.018
更新日期:2007-04-08 00:00:00
abstract::Aberrant expression of many long non-coding RNAs has been observed in various types of cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging knowledge with regard to the critical physiological and pathological roles of long non-coding RNAs in cancers makes them potential targets in ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.01.042
更新日期:2018-04-01 00:00:00
abstract::BRCA2-associated pancreatic ductal adenocarcinoma (PDAC) may be sensitive to agents that target homology-directed DNA repair, such as DNA crosslinking agents (DCLs) and PARP inhibitors (PARPis). Here, we assessed the sensitivities of BRCA2-deficient (Capan-1) and BRCA2-proficient (MIA PaCa-2) PDAC cell lines to a pane...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.04.003
更新日期:2015-08-01 00:00:00
abstract::The susceptibility of analbuminemic rats, a mutant strain of Sprague-Dawley rats, to bladder carcinogens was examined by testing the agglutinability of isolated bladder epithelial cells by Concanavalin A (Con A). One-week treatment with 0.001% N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN) in the drinking water or 0.01%...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90128-3
更新日期:1983-05-01 00:00:00
abstract::Increased abundance of the mRNA-binding protein human antigen R (HuR) is a characteristic feature of many cancers and frequently associated with a high grade malignancy and therapy resistance. HuR elicits a broad cell survival program mainly by stabilizing or increasing the translation of mRNAs coding for anti-apoptot...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.02.010
更新日期:2017-05-01 00:00:00
abstract::Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90344-1
更新日期:1994-02-28 00:00:00
abstract::We examined the responsiveness of normal and neoplastic lung cells to agents which stimulate cAMP production. While their basal cAMP levels were similar, spontaneous in vitro transformant E9 cells and tumor-derived PCC4 cells produced much less cAMP in response to 1 microM isoproterenol compared to non-tumorigenic C10...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90137-k
更新日期:1992-12-24 00:00:00
abstract::Cancers of the gastrointestinal (GI) tract continue to represent a major health problem, despite progress in therapy. Gut microbiota is a key element related to the genesis of GI cancers, countless papers addressing this burning issue across the world. We provide an updated knowledge of the involvement of gut microbio...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.08.013
更新日期:2014-04-10 00:00:00
abstract::Inactivation of antineoplastics is a serious problem in cancer therapy, and prevention of the inactivation is a surpassing strategy for enhancement of their therapeutic effects. BOF-A2, which contains both EM-FU, a masked form of 5-fluorouracil (5-FU), and CNDP, an inhibitor of 5-FU degradation, was developed with thi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00330-9
更新日期:1999-03-22 00:00:00
abstract::Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.05.004
更新日期:2009-11-28 00:00:00
abstract::Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90134-4
更新日期:1991-07-26 00:00:00
abstract::Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.01.007
更新日期:2011-04-28 00:00:00
abstract::Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. The compound irreversibly inhibited ornithine and S-adenosylmethione decarboxylases. This inhibitio...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90096-1
更新日期:1988-03-01 00:00:00
abstract::We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.08.012
更新日期:2009-01-18 00:00:00
abstract::The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inade...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.01.053
更新日期:2005-10-18 00:00:00
abstract::The past two decades have seen a dramatic change in cancer treatment paradigms. Anticancer agents are no longer being developed based on empiricism and serendipity, but are now being aimed to inhibit a validated target that is relatively specific for tumours rather than normal cells. The vast majority of cancers arise...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.03.012
更新日期:2007-01-08 00:00:00
abstract::Chimeric antigen receptor (CAR) T cell therapy is one of the most promising immunotherapies in the past decade. It brings hope for cure to patients with previously refractory hematological malignancies. However, when translating this strategy into non-hematologic malignancies, the antitumor activity from multiple clin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2021.01.014
更新日期:2021-01-19 00:00:00
abstract::Crk is a signaling adaptor protein which is mostly composed of SH2 and SH3 domains, and has been shown to play a pivotal role in cell proliferation, differentiation, and migration. Because Crk was originally isolated as an avian sarcoma virus CT10 encoding oncoprotein v-Crk, we examined a potential role for c-Crk in t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00763-7
更新日期:2002-06-06 00:00:00
abstract::Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.01.003
更新日期:2013-05-01 00:00:00
abstract::The role of the gastrointestinal microflora in the nitrate-dependent formation of nitrosoproline was assessed in control and antibiotic-treated rats. Urinary nitrosoproline excretion as an index of in vivo nitrosamine formation was shown to be unaffected by bacterial decontamination of the alimentary tract, and procee...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(84)80050-6
更新日期:1984-12-01 00:00:00
abstract::The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90113-5
更新日期:1980-04-01 00:00:00
abstract::Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.009
更新日期:2015-02-28 00:00:00
abstract::Transduction of the human interleukin-2 (IL-2) gene into tumor cells was carried out in order to develop a new immunotherapy for advanced head and neck carcinomas with a poor outcome. We transduced the IL-2 gene into KB cells, a head and neck squamous cell carcinoma cell line, using a defective herpes simplex viral (H...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00336-0
更新日期:2000-05-01 00:00:00
abstract::The retinoblastoma (Rb) gene is associated with the pathogenesis of several types of human cancer, including retinoblastoma, osteosarcoma, soft tissue sarcomas, and lung, breast and bladder carcinomas. Loss of heterozygosity is a common mode in allelic inactivation of Rb and other tumor-suppressor genes. We investigat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90099-u
更新日期:1993-07-30 00:00:00