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The missense mutations in the candidate prostate cancer gene ELAC2 do not alter enzymatic properties of its product.

Abstract：

:The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer. These enzymes were examined for the pre-tRNA cleavage and the RNase 65 activity. We did not observe any differences in enzymatic properties such as Km and k(cat) values between the wild-type tRNase ZL and its variants. We conclude that there is no causality between the enzymatic properties of tRNase ZL and the prostate cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Minagawa A,Takaku H,Takagi M,Nashimoto M

doi

10.1016/j.canlet.2004.09.013

keywords:

subject

Has Abstract

pub_date

2005-05-26 00:00:00

pages

211-5

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(04)00720-7

journal_volume

222

pub_type

杂志文章

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