Abstract:
:The mdm2 oncogene is amplified and overexpressed in a variety of human tumours and the oncogenic potential of MDM2 is partly due to its ability to inactivate tumour suppressor p53 function. In the present communication we describe the cloning, sequence analysis and expression of the complete wildtype canine and equine mdm2 cDNAs. The encoded full-length canine and equine cDNAs show strong sequence homology with MDM2 proteins from other species and both cDNAs generate recombinant proteins of approximately 90 kDa. These data will allow for the role of this oncogene to be established in companion animal oncology.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Nasir L,Burr PD,McFarlane ST,Gault E,Thompson H,Argyle DJdoi
10.1016/s0304-3835(99)00427-9keywords:
subject
Has Abstractpub_date
2000-04-28 00:00:00pages
9-13issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(99)00427-9journal_volume
152pub_type
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