Cellular uptake and photosensitizing properties of hematoporphyrin di-ethers with similar chromatographic properties as the tumorlocalizing fraction of hematoporphyrin derivative.

abstract：:Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...

journal_title：Cancer letters

authors： Bai D,Wu Y,Deol P,Nobumori Y,Zhou Q,Sladek FM,Liu X

更新日期：2021-01-01 00:00:00

abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...

journal_title：Cancer letters

authors： Tan W,Liao Y,Qiu Y,Liu H,Tan D,Wu T,Tang M,Zhang S,Wang H

更新日期：2018-08-01 00:00:00

abstract：:Sox17, a transcription factor, was considered as an antagonist to inhibit canonical Wnt/β-catenin signaling in several malignant tumors. Extremely little is known about Sox17 in gastric cancer. Therefore, the aim of this study was to elucidate the vital role of Sox17 in the tumorigenesis and progression of gastric can...

journal_title：Cancer letters

authors： Ye YW,Wu JH,Wang CM,Zhou Y,Du CY,Zheng BQ,Cao X,Zhou XY,Sun MH,Shi YQ

更新日期：2011-08-28 00:00:00

abstract：:The effects of treatment with naturally occurring antioxidants, selenium, beta-carotene, ferulic acid, esculin and eugenol during the promotional phase of tumor development were investigated in male F344 rats pre-treated with 1,2-dimethylhydrazine (DMH) and 1-methyl-1-nitrosourea (MNU). Animals were given 3 subcutaneo...

journal_title：Cancer letters

authors： Imaida K,Hirose M,Yamaguchi S,Takahashi S,Ito N

更新日期：1990-11-19 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...

journal_title：Cancer letters

authors： Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MR

更新日期：2014-12-01 00:00:00

abstract：:As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...

journal_title：Cancer letters

authors： Chen YL,Chang MC,Chiang YC,Lin HW,Sun NY,Chen CA,Sun WZ,Cheng WF

更新日期：2018-07-01 00:00:00

abstract：:The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...

journal_title：Cancer letters

authors： Jiang T,Mao Y,Ma W,Mao Q,You Y,Yang X,Jiang C,Kang C,Li X,Chen L,Qiu X,Wang W,Li W,Yao Y,Li S,Li S,Wu A,Sai K,Bai H,Li G,Chen B,Yao K,Wei X,Liu X,Zhang Z,Dai Y,Lv S,Wang L,Lin Z,Dong J,Xu G,M

更新日期：2016-06-01 00:00:00

abstract：:The occurrence and persistence of DNA fragmentation, as detected by the alkaline elution technique, have been studied in rats treated with single oral doses of the hepatocarcinogen 2-nitropropane (2-NP). A progressive increase of liver DNA fragmentation was observed at doses ranging from 0.5 to 8 mmol/kg; single stran...

journal_title：Cancer letters

authors： Robbiano L,Mattioli F,Brambilla G

更新日期：1991-04-01 00:00:00

abstract：:The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer...

journal_title：Cancer letters

authors： Minagawa A,Takaku H,Takagi M,Nashimoto M

更新日期：2005-05-26 00:00:00

abstract：:The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fol...

journal_title：Cancer letters

authors： Inui N,Nishi Y,Hasegawa MM,Kawachi T

更新日期：1980-05-01 00:00:00

abstract：:Evidence is growing that low folate status may be a factor in the aetiology of several cancers, including breast cancer. The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic. We report a case-control study of two functional polymorphisms in MTHFR, dietary fola...

journal_title：Cancer letters

authors： Sharp L,Little J,Schofield AC,Pavlidou E,Cotton SC,Miedzybrodzka Z,Baird JO,Haites NE,Heys SD,Grubb DA

更新日期：2002-07-08 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00

abstract：:Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...

journal_title：Cancer letters

authors： Stinson SF,Reznik G,Ward JM

更新日期：1981-03-01 00:00:00

abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

journal_title：Cancer letters

authors： Fu S,Chen X,Lo HW,Lin J

更新日期：2019-04-28 00:00:00

abstract：:An in vivo micronucleus assay using bone marrow cells of Syrian albino male mice for identifying the possibility of induction of adaptive response to various doses of radiation following treatment with chemotherapeutics is described. Single doses of bleomycin sulfate (BLM-S) at 300 micrograms/kg and actinomycin-D (ACT...

journal_title：Cancer letters

authors： Mozdarani H,Saberi AH

更新日期：1994-04-01 00:00:00

abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...

journal_title：Cancer letters

authors： Choo MK,Sakurai H,Koizumi K,Saiki I

更新日期：2005-12-08 00:00:00

abstract：:Lymphatic metastasis is the main route of breast cancer metastasis. It is known that lymphangiogenesis facilitates lymphatic metastasis through vascular endothelial growth factor-C (VEGF-C)/VEGF receptor 3 (VEGFR3) pathway-linked interactions between the tumor and its microenvironment. Here, we report a novel mechanis...

journal_title：Cancer letters

authors： Wang QS,He R,Yang F,Kang LJ,Li XQ,Fu L,Sun B,Feng YM

更新日期：2018-04-28 00:00:00

abstract：:14-3-3 sigma is a negative regulator of the cell cycle and contributes to G2 arrest. Thus far, the lack of its expression due to hypermethylation of the CpG islands has been reported in some carcinomas. In this study, we investigated the expression of 14-3-3 sigma in thyroid neoplasms by means of immunohistochemistry ...

journal_title：Cancer letters

authors： Ito Y,Miyoshi E,Uda E,Yoshida H,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Matsuura N,Kakudo K,Kuma K,Miyauchi A

更新日期：2003-10-28 00:00:00

abstract：:To further investigate the possibility for retroviral involvement in the etiology of human breast cancer we processed peripheral blood monocytes and malignant breast tissue biopsies from 10 patients with breast cancer (infiltrating ductal carcinoma or infiltrating lobular carcinoma; ages 40-80 years) and 20 normal hea...

journal_title：Cancer letters

authors： Hughes G,McKerr G,Allen J,Barnett Y

更新日期：1996-06-05 00:00:00

abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...

journal_title：Cancer letters

authors： Burnett JP,Lim G,Li Y,Shah RB,Lim R,Paholak HJ,McDermott SP,Sun L,Tsume Y,Bai S,Wicha MS,Sun D,Zhang T

更新日期：2017-05-28 00:00:00

abstract：:Rats bearing mammary carcinomas induced by N-nitroso-N-methylurea (NMU) were subjected to either no treatment (C), to ovariectomy (O), to continuous ketoconazole dosing at 400 ppm into the diet (K) or to both ovariectomy and ketoconazole dosing (O + K). In both C and K groups survival over the experimental period of 1...

journal_title：Cancer letters

authors： van Cauteren H,van den Berghe J,Hérin V,de Coster R,Marsboom R

更新日期：1984-09-01 00:00:00

abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...

journal_title：Cancer letters

authors： De Flora S,Astengo M,Serra D,Bennicelli C

更新日期：1986-09-01 00:00:00

abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

journal_title：Cancer letters

authors： Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

更新日期：1978-01-01 00:00:00

abstract：:Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained, neural progenitor...

journal_title：Cancer letters

authors： Tech K,Deshmukh M,Gershon TR

更新日期：2015-01-28 00:00:00

abstract：:Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...

journal_title：Cancer letters

authors： Wang CJ,Chou MY,Lin JK

更新日期：1989-11-30 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD10...

journal_title：Cancer letters

authors： Zhang C,Qiao H,Guo W,Liu Y,Yang L,Liu Y,Jin B,Fu M,Wang G,Li W

更新日期：2019-07-28 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were ...

journal_title：Cancer letters

authors： Wang D,Wang X,Si M,Yang J,Sun S,Wu H,Cui S,Qu X,Yu X

更新日期：2020-04-01 00:00:00

abstract：:In the present study, we tested the hypothesis that a mild cerebral tissue injury promotes subsequent glioma invasion via activation of the ADAM17-EGFR-PI3K-Akt pathway. Mild injury was induced by photodynamic therapy (PDT), which employs tissue-penetrating laser light exposure following systemic administration of a t...

journal_title：Cancer letters

authors： Zheng X,Jiang F,Katakowski M,Zhang X,Jiang H,Zhang ZG,Chopp M

更新日期：2008-07-08 00:00:00

abstract：:Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the ...

journal_title：Cancer letters

authors： Rodríguez-Martínez Á,Torres-Durán M,Barros-Dios JM,Ruano-Ravina A

更新日期：2018-07-10 00:00:00