Abstract：
:The occurrence and persistence of DNA fragmentation, as detected by the alkaline elution technique, have been studied in rats treated with single oral doses of the hepatocarcinogen 2-nitropropane (2-NP). A progressive increase of liver DNA fragmentation was observed at doses ranging from 0.5 to 8 mmol/kg; single strand breaks reached the maximum frequency 6 h after administration, and were partially reduced after 36 h. In contrast, DNA fragmentation was absent in lung, kidney, bone marrow and brain of rats given 8 mmol/kg. The role of cytochrome P-450 in the activation of 2-NP is indicated by the increase of liver DNA damage in rats pretreated with phenobarbital or beta-naphtoflavone, and by its reduction produced by methoxsalen. Both administration of GSH and GSH depletion did not result in clearcut modifications of the genotoxic effect of 2-NP for the liver.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Robbiano L,Mattioli F,Brambilla Gdoi
10.1016/0304-3835(91)90064-osubject
Has Abstractpub_date
1991-04-01 00:00:00pages
61-6issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(91)90064-Ojournal_volume
57pub_type
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