Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer.

abstract：:For biochemical modulation, components of green tea have been shown to be useful modulators in combination with doxorubicin (DOX). We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells. Because theanine is a glutamate analogue, we found that it is assoc...

journal_title：Cancer letters

authors： Sadzuka Y,Yamashita Y,Sugiyama T,Sonobe T

更新日期：2002-05-28 00:00:00

abstract：:The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. 1-Nitropyrene (greater than 99.5% purity) did not induce papilloma formation over a dose range of 0-3.0 mg/mouse after 30 weeks ...

journal_title：Cancer letters

authors： Nesnow S,Triplett LL,Slaga TJ

更新日期：1984-05-01 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-2...

journal_title：Cancer letters

authors： Ito Y,Ohigashi H,Koshimizu K,Yi Z

更新日期：1983-06-01 00:00:00

abstract：:Prevalence of human infection with Toxoplasma gondii has been increasing in China due to the increasing number of cats. However, little is known of the epidemiology of T. gondii infection in different cancer patient groups. Thus, a case-control study of 900 cancer patients and 900 controls was conducted to detect anti...

journal_title：Cancer letters

authors： Cong W,Liu GH,Meng QF,Dong W,Qin SY,Zhang FK,Zhang XY,Wang XY,Qian AD,Zhu XQ

更新日期：2015-04-10 00:00:00

abstract：:Overexpression of HER-2/neu proto-oncogene is found in many human cancers including 20-30% of breast cancer and is a predictor of poor prognosis. To target breast cancer cells that overexpress HER-2/neu mRNA, we previously described a novel strategy that combines the principle of antisense (AS) and translational inhib...

journal_title：Cancer letters

authors： Li Z,Xia W,Fang B,Yan DH

更新日期：2001-12-28 00:00:00

abstract：:We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%)...

journal_title：Cancer letters

authors： Iolascon A,Lo Cunsolo C,Giordani L,Cusano R,Mazzocco K,Boumgartner M,Ghisellini P,Faienza MF,Boni L,De Bernardi B,Conte M,Romeo G,Tonini GP

更新日期：1998-08-14 00:00:00

abstract：:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...

journal_title：Cancer letters

authors： Wang YS,Tsang YW,Chi CH,Chang CC,Chu RM,Chi KH

更新日期：2008-08-08 00:00:00

abstract：:Gastric cancer (GC) is a major threat to human health, and its prognosis is poor due to the lack of appropriate biomarkers. LncRNAs are a group of non-protein-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. LncRNAs play essential roles in GC initiation and development in ...

journal_title：Cancer letters

authors： Yang Z,Guo X,Li G,Shi Y,Li L

更新日期：2016-02-01 00:00:00

abstract：:Effects of the green tea catechins (GTCs) on the late promotion or progression stage of mammary gland carcinogenesis were examined in female Sprague-Dawley (SD) rats pretreated with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 84 7-week-old rats received a 50 mg/kg body weight intra-gastric dose of DMBA, and star...

journal_title：Cancer letters

authors： Hirose M,Mizoguchi Y,Yaono M,Tanaka H,Yamaguchi T,Shirai T

更新日期：1997-01-30 00:00:00

abstract：:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological ...

journal_title：Cancer letters

authors： Verkerk R,van der Gaag MS,Dekker M,Jongen WM

更新日期：1997-03-19 00:00:00

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...

journal_title：Cancer letters

authors： Oh BK,Seong JK,Lee JE,Chae KJ,Roh KJ,Park C,Park YN

更新日期：2002-12-01 00:00:00

abstract：:Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...

journal_title：Cancer letters

authors： Büssing A,Suzart K,Bergmann J,Pfüller U,Schietzel M,Schweizer K

更新日期：1996-01-19 00:00:00

abstract：:The scope of the structure-anticancer activity relationship among various aliphatic and aromatic hydrazones containing the N,N,N',N'-bis(1,2-ethanediyl)-phosphoric diamide moiety was studied. A total of 19 compounds were tested in vivo, using murine lymphocytic leukemia P388. At optimum dose all these compounds were a...

journal_title：Cancer letters

authors： Sosnovsky G,Rao NU

更新日期：1985-12-01 00:00:00

abstract：:As a cellular degradation mechanism, autophagy exerts crucial and complicated effects on HCC development. Liver non-parenchymal cells, including hepatic resident macrophage Kupffer cells, also play important roles in this process. However, most associated studies have focused on the influence of the autophagy level in...

journal_title：Cancer letters

authors： Sun K,Xu L,Jing Y,Han Z,Chen X,Cai C,Zhao P,Zhao X,Yang L,Wei L

更新日期：2017-03-01 00:00:00

abstract：:Cultures of normal human peripheral blood lymphocytes stimulated by phytohaemagglutinin (PHA) were treated with withaferin A and examined by an electron microscope. The compound was found to affect the spindle microtubules of cells in metaphase. There were no intact pole-to-pole microtubules or pole-to-kinetochore mic...

journal_title：Cancer letters

authors： Shohat B,Ben-Bassat M,Shaltiel A,Joshua H

更新日期：1976-11-01 00:00:00

abstract：:Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop ...

journal_title：Cancer letters

authors： Hata K,Tanaka T,Kohno H,Suzuki R,Qiang SH,Yamada Y,Oyama T,Kuno T,Hirose Y,Hara A,Mori H

更新日期：2006-07-28 00:00:00

abstract：:Virtually all cervical cancer morbidities are associated with genital skin or mucosa cell infection with human papillomavirus (HPV). The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation. Employing quantitative real-time PCR and Western blot analysis...

journal_title：Cancer letters

authors： Luczak MW,Jagodzinski PP

更新日期：2008-12-08 00:00:00

abstract：:Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 mumol of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal ca...

journal_title：Cancer letters

authors： Watson RR,Moriguchi S,Gensler HL

更新日期：1987-08-01 00:00:00

abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

journal_title：Cancer letters

authors： Parfett CL,Pilon R

更新日期：1993-07-30 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is one of the high population malignant tumors among Chinese in southern China and southeast Asia. Epstein-Barr virus (EBV) is a human B lymphotropic herpes virus which is known to be closely associated with NPC. EBV DNA polymerase is a key enzyme during EBV replication and is measured b...

journal_title：Cancer letters

authors： Lee MH,Chiou JF,Yen KY,Yang LL

更新日期：2000-06-30 00:00:00

abstract：:Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma. Intratumoral hypoxia, i.e. reduced oxygen supply following uncontrolled proliferation of cancer...

journal_title：Cancer letters

authors： Ullmann P,Nurmik M,Schmitz M,Rodriguez F,Weiler J,Qureshi-Baig K,Felten P,Nazarov PV,Nicot N,Zuegel N,Haan S,Letellier E

更新日期：2019-05-28 00:00:00

abstract：:Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...

journal_title：Cancer letters

authors： Tsokos GC,Choie DD

更新日期：1980-09-01 00:00:00

abstract：:In Mongolian gerbils, the gastric mucosa shows dramatic changes after Helicobacter pylori inoculation. The influence of the timing of N-methyl-N-nitrosourea (MNU) administration after H. pylori inoculation on gastric carcinogenesis was investigated. Ninety-two gerbils were divided into four groups. One group was given...

journal_title：Cancer letters

authors： Maruta F,Sugiyama A,Ishida K,Ikeno T,Murakami M,Kawasaki S,Ota H,Tatematsu M,Katsuyama T

更新日期：2000-11-10 00:00:00

abstract：:Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing. Male Fischer 344 rats, 6 weeks old...

journal_title：Cancer letters

authors： Tsujiuchi T,Kido A,Nakae D,Takahama M,Majima T,Kobitsu K,Okajima E,Tsutsumi M,Denda A,Konishi Y

更新日期：1996-11-12 00:00:00

abstract：:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a diff...

journal_title：Cancer letters

authors： Liu R,Wei S,Chen J,Xu S

更新日期：2014-10-28 00:00:00

abstract：:Okadaic acid, a potent tumor promoter and an inhibitor of protein phosphatase 1 and 2A, has also been characterized as an angiogenic inducer in the chorioallantoic membrane of the chick embryo. To elucidate the roles of okadaic acid on angiogenic processes, we conducted in vitro angiogenesis assays. In this study, we ...

journal_title：Cancer letters

authors： Kim YS,Ahn KH,Kim SY,Jeong JW

更新日期：2009-04-08 00:00:00

abstract：:Tocopherol, a well known tissue anti-oxidant, given before local X-ray irradiation of 2 transplantable rat tumours was previously found to increase significantly the effect of irradiation. In the present study tocopherol did not influence the development of tumour necroses during growth of a transplantable rat hepatom...

journal_title：Cancer letters

authors： Kågerud A,Klintenberg C,Lund N,Peterson HI

更新日期：1978-10-01 00:00:00

abstract：:The antitumor activity of cytokine-induced killer (CIK) cells can be increased by co-culturing them with tumor lysate-pulsed dendritic cells (tDCs); this phenomenon has been studied mainly at the population level. Using time-lapse imaging, we examined how CIK cells gather information from tDCs at the single-cell level...

journal_title：Cancer letters

authors： Lee HK,Kim YG,Kim JS,Park EJ,Kim B,Park KH,Kang JS,Hong JT,Kim Y,Han SB

更新日期：2016-08-10 00:00:00