Effects of processing conditions on glucosinolates in cruciferous vegetables.

Abstract:

:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological active compounds. Some compounds, for example isothiocyanates, show an anticarcinogenic action by inducing phase II biotransformation enzyme activity (Jongen, Proc. Nutr. Soc. 1996; 55: 433-446). Processing of brassica vegetables influences glucosinolate degradation and therefore the biological activity. We investigate the effects of processing conditions on glucosinolates and their breakdown products. Besides measurement of concentrations also the biological activity of these compounds will be analysed.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Verkerk R,van der Gaag MS,Dekker M,Jongen WM

doi

10.1016/s0304-3835(97)04661-2

subject

Has Abstract

pub_date

1997-03-19 00:00:00

pages

193-4

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(97)04661-2

journal_volume

114

pub_type

杂志文章
  • Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer.

    abstract::This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2003.10.032

    authors: Ishida H,Miwa H,Tatsuta M,Masutani S,Imamura H,Shimizu J,Ezumi K,Kato H,Kawasaki T,Furukawa H,Kawakami H

    更新日期:2004-04-15 00:00:00

  • Pancreatic carcinogenicity of N-nitrosobis(2-oxopropyl)-amine in diabetic and non-diabetic Chinese hamsters.

    abstract::To examine the role of diabetes in pancreatic cancer, 4 groups of Chinese hamsters--2 from genetically diabetic and 2 from non-diabetic lines--were treated with N-nitrosobis(2-oxo-propyl)amine (BOP) at different dose levels and intervals. In one group (referred to as the VA group), BOP was given weekly at a 5 mg/kg bo...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(87)90014-0

    authors: Bell RH Jr,Pour PM

    更新日期:1987-02-01 00:00:00

  • Photohemolysis of human erythrocytes induced by aluminum phthalocyanine tetrasulfonate.

    abstract::The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(86)90057-1

    authors: Ben-Hur E,Rosenthal I

    更新日期:1986-03-01 00:00:00

  • Effect of potent antiglucocorticoids on dexamethasone induced enzymes in cultured hepatoma and rat liver cells.

    abstract::The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation t...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(85)90192-2

    authors: Santana MA,Chasserot-Bolaz S,Beck B,Pogson CI

    更新日期:1985-07-01 00:00:00

  • Cancer metabolism and mass spectrometry-based proteomics.

    abstract::Cancer metabolism has been extensively investigated by various tools, and the fact of diverse metabolic reprogramming in cancer cells has been gradually unveiled. In this review, we discuss some contributions in cancer metabolism by general proteomic analysis and post-translational modification analysis using mass spe...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2013.11.003

    authors: Zhou W,Liotta LA,Petricoin EF

    更新日期:2015-01-28 00:00:00

  • Mammaglobin B gene as a novel marker for lymph node micrometastasis in patients with abdominal cancers.

    abstract::Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00378-x

    authors: Aihara T,Fujiwara Y,Miyake Y,Okami J,Okada Y,Iwao K,Sugita Y,Tomita N,Sakon M,Shiozaki H,Monden M

    更新日期:2000-03-13 00:00:00

  • Cytotoxicity of PAI2, C595 and Herceptin vectors labeled with the alpha-emitting radioisotope Bismuth-213 for ovarian cancer cell monolayers and clusters.

    abstract::The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2005.03.060

    authors: Song YJ,Qu CF,Rizvi SM,Li Y,Robertson G,Raja C,Morgenstern A,Apostolidis C,Perkins AC,Allen BJ

    更新日期:2006-03-28 00:00:00

  • Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.

    abstract::Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(82)90023-4

    authors: Wong LM,Bern HA,Jones LA,Mills KT

    更新日期:1982-11-01 00:00:00

  • Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica.

    abstract::The South American opossum, Monodelphis domestica, has been used as a model system to study ultraviolet (UV)-induced genetic alterations that lead to the development of melanoma. Suckling young of Monodelphis exposed to multiple doses of UVB radiation can develop benign or malignant melanomas later as adults. Point mu...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00783-2

    authors: Chan J,Robinson ES,Yeh IT,McCarrey JR

    更新日期:2002-10-08 00:00:00

  • Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas.

    abstract::Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.01.018

    authors: Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

    更新日期:2004-07-16 00:00:00

  • Oncogenic potential of BRAF versus RAS.

    abstract::Mutations in the ERK pathway occur in approximately one-third of all human cancers and most often involve production of mutant RAS or BRAF. Several studies, including our own, have shown that mutations in the BRAF and RAS genes are generally mutually exclusive. This study was performed to determine the relative oncoge...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2007.10.033

    authors: Benjamin CL,Ananthaswamy HN

    更新日期:2008-03-18 00:00:00

  • RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.

    abstract::We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.03.004

    authors: Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

    更新日期:2011-07-28 00:00:00

  • DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway.

    abstract::Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells, however, the precise molecular mechanisms of apoptosis in vitro are unclear. In this study, we showed that curcumin, a plant product containing the phenolic phytochemical...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.06.031

    authors: Lin SS,Huang HP,Yang JS,Wu JY,Hsia TC,Lin CC,Lin CW,Kuo CL,Gibson Wood W,Chung JG

    更新日期:2008-12-08 00:00:00

  • In vitro upregulation of carcinoembryonic antigen expression by combinations of cytokines.

    abstract::Interferons are able to enhance the expression of carcinoembryonic antigen (CEA) on tumour cells, allowing improved tumour targeting. In this report the hypothesis is tested that combinations of cytokines may further increase the tumour antigen expression. The combination of both IFN-gamma and IFN-alpha with interleuk...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00007-5

    authors: Verhaar MJ,Damen CA,Zonnenberg BA,Blijham GH

    更新日期:1999-05-03 00:00:00

  • Cisplatin and nifedipine: synergistic cytotoxicity against murine solid tumors and their metastases.

    abstract::Calcium channel blockers of 3 chemical classes and calmodulin antagonists have recently been shown to enhance the cytotoxicity of conventional cancer chemotherapeutic agents. We tested the ability of nifedipine, a dihydropyridine class calcium channel blocker, to enhance the cytotoxicity of cisplatin, the current chem...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(86)90087-x

    authors: Onoda JM,Jacobs JR,Taylor JD,Sloane BF,Honn KV

    更新日期:1986-02-01 00:00:00

  • Antibody-induced apoptosis in a human leukemia cell line is energy dependent: thermochemical analysis of cellular metabolism.

    abstract::The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(93)90194-e

    authors: Wallén-Ohman M,Lönnbro P,Schön A,Borrebaeck CA

    更新日期:1993-12-10 00:00:00

  • Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.

    abstract::We investigated the molecular effects of 3,4,2',4'-tetrahydroxychalcone (butein) treatment in two human hepatoma cancer cell lines-HepG2 and Hep3B. Butein treatment inhibited cancer cell growth by inducing G(2)/M phase arrest and apoptosis. Butein-induced G(2)/M phase arrest was associated with increased ATM, Chk1, an...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2009.07.002

    authors: Moon DO,Kim MO,Choi YH,Hyun JW,Chang WY,Kim GY

    更新日期:2010-02-28 00:00:00

  • Epigenetic biomarkers in skin cancer.

    abstract::Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2012.01.020

    authors: Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DS

    更新日期:2014-01-28 00:00:00

  • Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.

    abstract::Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.06.020

    authors: Rho SB,Byun HJ,Park SY,Chun T

    更新日期:2008-11-28 00:00:00

  • The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs.

    abstract::Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2014.07.028

    authors: Tang S,Yang L,Tang X,Liu M

    更新日期:2014-10-28 00:00:00

  • A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

    abstract::In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2013.01.022

    authors: Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

    更新日期:2013-05-10 00:00:00

  • The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway.

    abstract::Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2008.09.008

    authors: Bastian P,Balcarek A,Altanis C,Strell C,Niggemann B,Zaenker KS,Entschladen F

    更新日期:2009-02-18 00:00:00

  • Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential.

    abstract::We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras on...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(00)00421-3

    authors: Sato N,Mizumoto K,Beppu K,Maehara N,Kusumoto M,Nabae T,Morisaki T,Katano M,Tanaka M

    更新日期:2000-07-31 00:00:00

  • Non-random structural chromosomal changes in ovarian cancer: i(5p) a novel recurrent abnormality.

    abstract::Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2005.04.010

    authors: Panani AD,Roussos C

    更新日期:2006-04-08 00:00:00

  • Antisense lncRNA FOXC2-AS1 promotes doxorubicin resistance in osteosarcoma by increasing the expression of FOXC2.

    abstract::Recent efforts have revealed that numerous natural antisense lncRNAs play a crucial role in the regulation of cancer biology. Here, based on our previous study, we further identified that the lncRNA FOXC2-AS1 and its antisense transcript FOXC2 are positively up-regulated in doxorubicin-resistant osteosarcoma cell line...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2017.03.018

    authors: Zhang CL,Zhu KP,Ma XL

    更新日期:2017-06-28 00:00:00

  • Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells.

    abstract::The purpose of this study was to investigate the possible role of PI-3K/Akt2 pathway in docetaxel-induced apoptosis. Here we showed that transfection of full-length Akt2 into breast and ovarian cancer cells could provoke Akt phosphorylation and induce an enhanced resistance to docetaxel. FN adhesion promoted Akt phosp...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2007.11.022

    authors: Xing H,Weng D,Chen G,Tao W,Zhu T,Yang X,Meng L,Wang S,Lu Y,Ma D

    更新日期:2008-03-08 00:00:00

  • Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system.

    abstract::Patients with a basal cell carcinomas (BCC) have an increased risk of further tumors. We studied the individual and combined impact of gender, skin type and allelic genes cytochrome P450 (CYP2D6), vitamin D receptor (VDR), tumor necrosis factor-alpha, TNF-alpha) on the rate of increase in BCC numbers after first prese...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(02)00516-5

    authors: Ramachandran S,Fryer AA,Lovatt TJ,Smith AG,Lear JT,Jones PW,Strange RC

    更新日期:2003-01-28 00:00:00

  • The ineffectiveness of reduced glutathione in preventing the development of liver tumours from aflatoxin-induced pre-neoplastic liver lesions.

    abstract::Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(83)90086-1

    authors: Neal GE,Legg RF

    更新日期:1983-11-01 00:00:00

  • Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability.

    abstract::Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2007.02.004

    authors: Miyamoto N,Yamamoto H,Taniguchi H,Miyamoto C,Oki M,Adachi Y,Imai K,Shinomura Y

    更新日期:2007-08-28 00:00:00

  • 4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice.

    abstract::Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-indu...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.02.028

    authors: Guo H,Li M,Chen P,Blake DJ,Kong X,Hao X,Niu R,Zhang N

    更新日期:2011-06-01 00:00:00