Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells.

abstract：:Mantle cell lymphoma (MCL) is an aggressive and incurable mature B cell neoplasm. The current treatments are based on chemotherapeutics and new class of drugs (e.g. Ibrutinib(®)), which in most cases ends with tumor resistance and relapse. Therefore, further development of novel therapeutic modalities is needed. Exoso...

journal_title：Cancer letters

authors： Hazan-Halevy I,Rosenblum D,Weinstein S,Bairey O,Raanani P,Peer D

更新日期：2015-08-01 00:00:00

abstract：:Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI and membrane both bound reactive substances of limited aqueous stability, such as from [14C]N-methyl-N-nitrosourea ([14C]NMU), and aqueous stable dyes of molecula...

journal_title：Cancer letters

authors： Povey AC,Bartsch H,O'Neill IK

更新日期：1987-07-01 00:00:00

abstract：:The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects o...

journal_title：Cancer letters

authors： Lee HJ,Lee WK,Kang CW,Ku CR,Cho YH,Lee EJ

更新日期：2018-03-28 00:00:00

abstract：:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

journal_title：Cancer letters

authors： Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

更新日期：1999-10-18 00:00:00

abstract：:Currently, chemoresistance is an important cause of treatment failure in colorectal cancer. Cancer stem cells, which are a population of multi-potent cells with the capacity to self-renew and differentiate, have been found to participate in chemoresistance. In the present study, the chemotherapeutic drug oxaliplatin i...

journal_title：Cancer letters

authors： Yang HZ,Ma Y,Zhou Y,Xu LM,Chen XJ,Ding WB,Zou HB

更新日期：2015-05-28 00:00:00

abstract：:Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...

journal_title：Cancer letters

authors： Zhou H,Xu W,Qian H,Yin Q,Zhu W,Yan Y

更新日期：2008-01-18 00:00:00

abstract：:The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...

journal_title：Cancer letters

authors： Pierson HF,Meadows GG

更新日期：1985-11-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...

journal_title：Cancer letters

authors： Qiao J,Kang J,Ko TC,Evers BM,Chung DH

更新日期：2006-10-28 00:00:00

abstract：:MICAL2 is a tumor-promoting factor involved in cell migration, invasion, deformation, and proliferation not yet fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and cytoplasm-enriched in LUAD tissues. Moreover, high cytoplasmic MICAL2 and/or total MICAL2 expression le...

journal_title：Cancer letters

authors： Zhou W,Liu Y,Gao Y,Cheng Y,Chang R,Li X,Zhou Y,Wang S,Liang L,Duan C,Zhang C

更新日期：2020-07-28 00:00:00

abstract：:During a follow-up program, breast cancer patients were monitored with serum analyses of mucin-like carcinoma-associated antigen (MCA), CA 15.3 and carcinoembryonic antigen (CEA). Minimum as well as maximum marker values of the individual patterns were selected for further evaluation. Marker levels of risk patients di...

journal_title：Cancer letters

authors： Bieglmayer C,Szepesi T,Neunteufel W

更新日期：1988-11-01 00:00:00

abstract：:Patients with inadequate anti-cancer T cell responses experience limited benefit from immune checkpoint inhibitors and other immunotherapies that require T cells. Therefore, treatments that induce de novo anti-cancer T cell immunity are needed. One strategy - referred to as in situ vaccination - is to deliver chemothe...

journal_title：Cancer letters

authors： Lynn GM,Laga R,Jewell CM

更新日期：2019-09-10 00:00:00

abstract：:Inhibition of 5-Lox induces apoptosis in prostate cancer cells by inactivating PKCε which is prevented by 5-oxoETE, and activators of PKCε prevent 5-Lox inhibition-induced apoptosis, suggesting that 5-Lox metabolites exert survival signaling via PKCε. However, mechanisms by which 5-Lox metabolites activate PKCε are no...

journal_title：Cancer letters

authors： Sarveswaran S,Ghosh J

更新日期：2013-08-09 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized end...

journal_title：Cancer letters

authors： Goto H,Matsuda K,Srikoon P,Kariya R,Hattori S,Taura M,Katano H,Okada S

更新日期：2013-05-01 00:00:00

abstract：:More than 50% of human tumors contain a mutation in p53. Over 90% of tumors are solid tumors. Solid tumors have low oxygenated regions, called hypoxic regions where the tumor cells are more resistant to radio- and chemo-therapy than their well-oxygenated counterparts. In this study, we constructed a cell-permeable p53...

journal_title：Cancer letters

authors： Yu Z,Wu J,Wu S,Jia P,Tong Y,Wu X,Wang Y

更新日期：2009-06-28 00:00:00

abstract：:The oral administration of a single 20mg dose of 7,12-dimethylbenz[a]anthracene regularly and rapidly induces mammary cancer in 50 day-old Sprague-Dawley female rats [Experimental Leukemia and Mammary Cancer, 1979, p. 74]. Several mechanisms by which 7,12-dimethylbenz[a]anthracene induces mammary cancer have been prop...

journal_title：Cancer letters

authors： Horn J,Lehner AF,Flesher JW

更新日期：2005-04-08 00:00:00

abstract：:The RNA expression levels of human catalytic subunit (TERT) and the RNA subunit (TR) of telomerase were analysed after treatment with the agonists of the membrane receptor (S 20098) and the nuclear receptor (CGP 52608) for melatonin in the MCF-7 human breast tumor cell line. Neither membrane nor nuclear signalling aff...

journal_title：Cancer letters

authors： Leon-Blanco MM,Guerrero JM,Reiter RJ,Pozo D

更新日期：2004-12-08 00:00:00

abstract：:Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...

journal_title：Cancer letters

authors： Fukushima M,Kuzuya K,Ota K,Ikai K

更新日期：1981-12-01 00:00:00

abstract：:Several clinical protocols are attempting to utilize the combined anti-proliferative signal of interferon-alpha (INF-alpha) and tamoxifen on cancer cells. We demonstrated here that the effect of these two agents on the growth of the premacrophage U937 cells is antagonistic. This antagonistic effect is paralleled by th...

journal_title：Cancer letters

authors： Balint E,Grimley PM,Michalic R,Aszalos A

更新日期：1992-10-30 00:00:00

abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

journal_title：Cancer letters

authors： Fu S,Chen X,Lo HW,Lin J

更新日期：2019-04-28 00:00:00

abstract：:Multidrug-resistant MCF-7 breast adenocarcinoma cells (originally named MCF-7/AdrR cells and later re-designated NCI/ADR-RES) have served as an important and widely used research tool during the last two decades. However, the real identity of these cells has been in doubt since 1998 and has since been debated. The ori...

journal_title：Cancer letters

authors： Liscovitch M,Ravid D

更新日期：2007-01-08 00:00:00

abstract：:The intracellular androgen metabolism and cell activity in prostate cancer cells with mutated (LNCaP-FGC) or wild-type (VCaP) androgen receptors in the presence of trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, were examined. Trilostane suppressed the intracellular production of androstenedione, testoste...

journal_title：Cancer letters

authors： Takizawa I,Nishiyama T,Hara N,Hoshii T,Ishizaki F,Miyashiro Y,Takahashi K

更新日期：2010-11-28 00:00:00

abstract：:Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4',6-diamidino-2-pheny...

journal_title：Cancer letters

authors： Kapuscinski J,Traganos F,Darzynkiewicz Z

更新日期：1988-11-01 00:00:00

abstract：:Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

journal_title：Cancer letters

authors： Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

更新日期：1992-09-30 00:00:00

abstract：:Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...

journal_title：Cancer letters

authors： Sminia P,van der Kleij AJ,Carl UM,Feldmeier JJ,Hartmann KA

更新日期：2003-02-28 00:00:00

abstract：:Co-transfer of immunomodulatory and antiproliferative genes may be the basis for new strategies to potentiate tumor regression. In this study, we evaluated the in vitro effect of the introduction of human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes via recombinant adenoviru...

journal_title：Cancer letters

authors： Qiu ZH,Wu CT,Lao MF,Pan LZ,Li YM

更新日期：2002-08-28 00:00:00

abstract：:Lung cancer is a heterogeneous disease that is impacted by environmental exposures and by constitutional genetic or epigenetic susceptibilities to disease development and progression. The United States and China have distinct and diverse populations and geographic environmental exposures that contribute to unique patt...

journal_title：Cancer letters

authors： Yang D,Liu Y,Bai C,Wang X,Powell CA

更新日期：2020-01-01 00:00:00

abstract：:Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characterized human serine protease granzyme B has already been used as a the...

journal_title：Cancer letters

authors： Niesen J,Hehmann-Titt G,Woitok M,Fendel R,Barth S,Fischer R,Stein C

更新日期：2016-05-01 00:00:00

abstract：:Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here, we investigated the molecular mechanism by which EB1 regulates apoptosis in H460, A549, and H1299 cells. Depletion of EB1 in A549 and H1299...

journal_title：Cancer letters

authors： Kim MJ,Yun HS,Hong EH,Lee SJ,Baek JH,Lee CW,Yim JH,Kim JS,Park JK,Um HD,Hwang SG

更新日期：2013-10-01 00:00:00

abstract：:Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells, however, the precise molecular mechanisms of apoptosis in vitro are unclear. In this study, we showed that curcumin, a plant product containing the phenolic phytochemical...

journal_title：Cancer letters

authors： Lin SS,Huang HP,Yang JS,Wu JY,Hsia TC,Lin CC,Lin CW,Kuo CL,Gibson Wood W,Chung JG

更新日期：2008-12-08 00:00:00

abstract：:C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L...

journal_title：Cancer letters

authors： Petersen TR,Bregenholta S,Pedersen LO,Nissen MH,Claesson MH

更新日期：1999-04-01 00:00:00