Abstract：
:Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in squamous cells decreased during maturation. Correspondingly, superficial cells appearing in smear specimens had less nuclear fluorescence compared with parabasal cells in the same smear. However, cancer cells in cervical smears had marked nuclear fluorescence using immunostaining and were easily distinguished from normal cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fukushima M,Kuzuya K,Ota K,Ikai Kdoi
10.1016/0304-3835(81)90148-8subject
Has Abstractpub_date
1981-12-01 00:00:00pages
227-36issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(81)90148-8journal_volume
14pub_type
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