Abstract：
:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis revealed that miR-135b affects a regulator that inhibits hypoxia-inducible factor (HIF). Increased miR-135b expression was positively correlated with HIF-1α expression and microvessel density in the HNSCC model. Thus, our data demonstrate that miR-135b acts as a tumor promoter by promoting cancer cell proliferation, colony formation, survival, and angiogenesis through activation of HIF-1α in HNSCC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zhang L,Sun ZJ,Bian Y,Kulkarni ABdoi
10.1016/j.canlet.2013.01.003subject
Has Abstractpub_date
2013-05-01 00:00:00pages
230-8issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(13)00022-0journal_volume
331pub_type
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