Tumor-tagging by oncolytic viruses: A novel strategy for CAR-T therapy against solid tumors.

abstract：:Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of guduchi extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, met...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V,Vidyasagar MS

更新日期：1998-05-15 00:00:00

abstract：:The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...

journal_title：Cancer letters

authors： Tavolari S,Munarini A,Storci G,Laufer S,Chieco P,Guarnieri T

更新日期：2012-08-28 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer with poor prognosis. Despite extensive efforts, the current treatment methods have limited success. Therefore, novel therapeutic approaches are required. The pancreatic tumor microenvironment is rich in growth factors and inflammato...

journal_title：Cancer letters

authors： Roshani R,McCarthy F,Hagemann T

更新日期：2014-04-10 00:00:00

abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

journal_title：Cancer letters

authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

更新日期：2003-02-20 00:00:00

abstract：:In our previous rat study, an established intracranial C6 glioma was successfully treated using intratumoral injection of mesenchymal stem cells transduced with the herpes simplex virus-thymidine kinase gene (MSCtk) and systemic administration of ganciclovir (GCV). In the present study, effect of the "bystander effect...

journal_title：Cancer letters

authors： Amano S,Gu C,Koizumi S,Tokuyama T,Namba H

更新日期：2011-07-01 00:00:00

abstract：:Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas are cytogenetically characterized by the presence of supernumerary ring or giant chromosomes containing amplified material from the 12q14-15 region. These chromosomes contain neocentromeres, which are able to bind the kinetochore proteins and t...

journal_title：Cancer letters

authors： Italiano A,Maire G,Sirvent N,Nuin PA,Keslair F,Foa C,Louis C,Aurias A,Pedeutour F

更新日期：2009-01-18 00:00:00

abstract：:Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting C...

journal_title：Cancer letters

authors： Bancher-Todesca D,Rosen A,Graf A,Wasicky R,Hohlagschwandtner M,Rebhandl W,Heinze G,Breitenecker G,Gitsch G,Obermair A

更新日期：1999-07-01 00:00:00

abstract：:The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...

journal_title：Cancer letters

authors： Adachi S,Natsume H,Yamauchi J,Matsushima-Nishiwaki R,Joe AK,Moriwaki H,Kozawa O

更新日期：2009-05-08 00:00:00

abstract：:To determine Toxoplasma gondii antibodies in cancer patients, 267 cancer patients were studied using ELISA and higher positivity rates of T. gondii IgG were detected than the control. The positivity rates of T. gondii IgG in nasopharyngeal carcinoma, rectal cancer groups were significantly higher than the other cancer...

journal_title：Cancer letters

authors： Yuan Z,Gao S,Liu Q,Xia X,Liu X,Liu B,Hu R

更新日期：2007-08-28 00:00:00

abstract：:Pancreatic cancer is a malignant disease without efficient treatment. Improved treatments are urgently needed to enhance or replace chemotherapy. Here we used a small molecular compound LB-100 to assess the effect of pharmacological inhibition of protein phosphatase 2A (PP2A) in combination with doxorubicin on the pro...

journal_title：Cancer letters

authors： Bai X,Zhi X,Zhang Q,Liang F,Chen W,Liang C,Hu Q,Sun X,Zhuang Z,Liang T

更新日期：2014-12-28 00:00:00

abstract：:Several clinical protocols are attempting to utilize the combined anti-proliferative signal of interferon-alpha (INF-alpha) and tamoxifen on cancer cells. We demonstrated here that the effect of these two agents on the growth of the premacrophage U937 cells is antagonistic. This antagonistic effect is paralleled by th...

journal_title：Cancer letters

authors： Balint E,Grimley PM,Michalic R,Aszalos A

更新日期：1992-10-30 00:00:00

abstract：:Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has ...

journal_title：Cancer letters

authors： Aida S,Sonobe Y,Tanimura H,Oikawa N,Yuhki M,Sakamoto H,Mizuno T

更新日期：2017-11-28 00:00:00

abstract：:Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main asp...

journal_title：Cancer letters

authors： Tang B,Hsu PY,Huang TH,Jin VX

更新日期：2013-11-01 00:00:00

abstract：:We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...

journal_title：Cancer letters

authors： Kim ES,Sohn YW,Moon A

更新日期：2007-07-08 00:00:00

abstract：:The effects of treatment with naturally occurring antioxidants, selenium, beta-carotene, ferulic acid, esculin and eugenol during the promotional phase of tumor development were investigated in male F344 rats pre-treated with 1,2-dimethylhydrazine (DMH) and 1-methyl-1-nitrosourea (MNU). Animals were given 3 subcutaneo...

journal_title：Cancer letters

authors： Imaida K,Hirose M,Yamaguchi S,Takahashi S,Ito N

更新日期：1990-11-19 00:00:00

abstract：:Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussuscept...

journal_title：Cancer letters

authors： Ribatti D,Djonov V

更新日期：2012-03-28 00:00:00

abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

journal_title：Cancer letters

authors： Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

更新日期：2002-12-10 00:00:00

abstract：:Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

journal_title：Cancer letters

authors： Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

更新日期：1991-05-24 00:00:00

abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

journal_title：Cancer letters

authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

更新日期：2016-05-01 00:00:00

abstract：:The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the ca...

journal_title：Cancer letters

authors： Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PP

更新日期：1996-07-12 00:00:00

abstract：:In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...

journal_title：Cancer letters

authors： Chanda R,Ganguly AK

更新日期：1987-02-01 00:00:00

abstract：:miRNAs are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional and translational levels. miRNA-451 was previously reported to be down-regulated in gastric and colorectal cancers. Here, we showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues an...

journal_title：Cancer letters

authors： Wang XC,Tian LL,Jiang XY,Wang YY,Li DG,She Y,Chang JH,Meng AM

更新日期：2011-12-08 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 ...

journal_title：Cancer letters

authors： da Silva TC,Paula da Silva A,Akisue G,Luis Avanzo J,Kazumi Nagamine M,Fukumasu H,Matsuzaki P,César Raspantini P,Haraguchi M,Lima Górniak S,Dagli ML

更新日期：2005-08-26 00:00:00

abstract：:We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...

journal_title：Cancer letters

authors： Reynolds S,Rajagopal S,Chakrabarty S

更新日期：1998-12-11 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...

journal_title：Cancer letters

authors： Chiappini E,Berti E,Gianesin K,Petrara MR,Galli L,Giaquinto C,de Martino M,De Rossi A

更新日期：2014-05-28 00:00:00

abstract：:We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...

journal_title：Cancer letters

authors： Ishiguro S,Sasazuki S,Inoue M,Kurahashi N,Iwasaki M,Tsugane S,JPHC Study Group.

更新日期：2009-03-18 00:00:00

abstract：:The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...

journal_title：Cancer letters

authors： Zhou A,Tang L,Zeng S,Lei Y,Yang S,Tang B

更新日期：2020-04-01 00:00:00

abstract：:Co-transfer of immunomodulatory and antiproliferative genes may be the basis for new strategies to potentiate tumor regression. In this study, we evaluated the in vitro effect of the introduction of human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes via recombinant adenoviru...

journal_title：Cancer letters

authors： Qiu ZH,Wu CT,Lao MF,Pan LZ,Li YM

更新日期：2002-08-28 00:00:00