Abstract:
:miRNAs are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional and translational levels. miRNA-451 was previously reported to be down-regulated in gastric and colorectal cancers. Here, we showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues and that its expression was negatively associated with lymph node metastasis, the stage of TNM classification and poor prognosis of NSCLC patients. Moreover, significantly different miRNA-451 expression levels were found between smoking and non-smoking patients. The overexpression of miRNA-451 inhibited cell cycle progression, cellular migration and the invasive ability of NSCLC cells. Increased miRNA-451 expression also promoted anoikis of NSCLC cells. Together, these data suggested that aberrantly expressed miRNA-451 may be associated with the development of NSCLC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang XC,Tian LL,Jiang XY,Wang YY,Li DG,She Y,Chang JH,Meng AMdoi
10.1016/j.canlet.2011.07.026subject
Has Abstractpub_date
2011-12-08 00:00:00pages
203-9issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00451-4journal_volume
311pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.09.012
更新日期:2016-12-01 00:00:00
abstract::We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.07.034
更新日期:2016-10-10 00:00:00
abstract::The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.04.025
更新日期:2009-11-01 00:00:00
abstract::Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell pr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.02.008
更新日期:2010-08-28 00:00:00
abstract::Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.01.003
更新日期:2013-05-01 00:00:00
abstract::We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00242-0
更新日期:1998-12-11 00:00:00
abstract::Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain met...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.07.001
更新日期:2011-12-08 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly lethal malignancy mostly because of de novo and acquired resistance to conventional chemotherapy. Constitutive activation of Akt and nuclear factor-κB (NF-κB) represent major cellular abnormalities associated with both the pathogenesis and therapeutic resistance of HCC. The a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.10.022
更新日期:2011-02-01 00:00:00
abstract::We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.01.014
更新日期:2010-07-28 00:00:00
abstract::Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90039-k
更新日期:1991-06-14 00:00:00
abstract::The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00275-6
更新日期:2002-11-28 00:00:00
abstract::We present the data of 105 serum samples from 20 patients suffering from cervical cancer. Mean serum levels of basic fibroblast growth factor (bFGF) in patients with or without tumor present were 31.3 +/- 32.1 (minimum 0, maximum 156.7) pg/ml and 4.8 +/- 6.8 (minimum 0, maximum 29.6) pg/ml, respectively (P = 0.0001). ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03853-o
更新日期:1995-08-01 00:00:00
abstract::Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.02.016
更新日期:2018-05-01 00:00:00
abstract::The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(82)90092-1
更新日期:1982-05-01 00:00:00
abstract::scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion proteins with C-terminal p53 peptides and tested for restoring p53 function in p53 mutant cancer cells. scFv fragments transported a 30-mer C-terminal peptide of p53 into cancer cells and induced cellul...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00151-4
更新日期:2003-06-10 00:00:00
abstract::The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.09.013
更新日期:2005-05-26 00:00:00
abstract::To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoiet...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.03.003
更新日期:2014-06-28 00:00:00
abstract::Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.03.018
更新日期:2013-08-19 00:00:00
abstract::The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.09.024
更新日期:2014-02-01 00:00:00
abstract::A single tumorigenic dose of methylazoxymethanol acetate increased adenylate cyclase activity in total liver homogenates 70-100% by the seventh day after treatment. The increased activity occurred in the plasma membranes rather than in the nuclei and was accompanied by a significant increase in 5'-nucleotidase activit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(75)95764-x
更新日期:1975-11-01 00:00:00
abstract::To improve the knowledge of the underlying mechanisms of action involved in air pollution Particulate Matter (PM)-induced toxicity in human lungs, with a particular interest of the crucial role played by coated-organic chemicals, we were interested in the metabolic activation of Polycyclic Aromatic Hydrocarbons (PAH)-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.04.044
更新日期:2008-10-18 00:00:00
abstract:INTRODUCTION/HYPOTHESIS:Over-expression of the c-Met receptor tyrosine kinase has been described in a variety of cancers and implicated in tumor progression. Unlike some solid tumors, current evidence indicates that c-Met activation in colon cancer is unrelated to gene mutation, is ligand dependent, and occurs via a pa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.07.007
更新日期:2007-04-18 00:00:00
abstract::Chemical agents including 5-iodo-2'-deoxyuridine (IUdR), 4-O-methyl 12-O-tetradecanoyl phorbol-13-acetate (TPA), phorbol, and the tumor promoters teleocidin and TPA were tested for their ability to induce Human T-cell leukemia-lymphoma virus Type I (HTLV-I) expression in the low-virus producer MT-1 cell line and in th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90077-8
更新日期:1988-04-01 00:00:00
abstract::Cancer stem cells (CSCs) are a sub-population of cancer cells that possess characteristics associated with normal stem cells but with the peculiarity that they are tumourigenic. This property allows them to persist in the tumour population, causing relapse and metastasis by giving rise to new tumours. Accordingly, if ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.04.020
更新日期:2013-09-10 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in Southern China and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor prognosis. The emergence of single-cell sequencing represents a powerful tool to resolve tumor heterogeneity and delineate the complex communicat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.02.010
更新日期:2020-05-01 00:00:00
abstract::Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2004.11.065
更新日期:2005-10-18 00:00:00
abstract::Expression of the MUC2 gene is controlled by the methylation of CpG sites in the promoter region, but the detailed methylation status of this region has yet to be reported. We have mapped the complete methylation status of the MUC2 promoter from position -1989 to position +288 upstream, a region that contains 59 CpG s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.058
更新日期:2005-09-28 00:00:00
abstract::Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90023-7
更新日期:1988-01-01 00:00:00
abstract::The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90175-8
更新日期:1986-09-01 00:00:00
abstract::The occurrence and persistence of DNA fragmentation, as detected by the alkaline elution technique, have been studied in rats treated with single oral doses of the hepatocarcinogen 2-nitropropane (2-NP). A progressive increase of liver DNA fragmentation was observed at doses ranging from 0.5 to 8 mmol/kg; single stran...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90064-o
更新日期:1991-04-01 00:00:00