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Cancer omics: from regulatory networks to clinical outcomes.

Abstract：

:Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main aspects of current genomics research with its application in cancer topics. We will first overview the next-generation sequencing technologies, then outline the major computational approaches, particularly focusing on ChIP-based omics data, and list several remaining open questions facing computational biologists, further present regulatory network analysis inferred from the ChIP-based omics data; finally implicate the clinical outcomes from the network and pathway analysis.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Tang B,Hsu PY,Huang TH,Jin VX

doi

10.1016/j.canlet.2012.11.033

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

277-83

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(12)00691-X

journal_volume

340

pub_type

杂志文章,评审

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