Effects of the pineal hormone melatonin on the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system.

abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...

journal_title：Cancer letters

authors： Li CJ,Chu CY,Huang LH,Wang MH,Sheu LF,Yeh JI,Hsu HY

更新日期：2012-06-28 00:00:00

abstract：:The combined application of N-methyl-N-nitrosourea (MNU) and 7,12-dimethylbenz[alpha]anthracene (DMBA) was compared with the administration of each carcinogen alone as to the effectiveness of the induction of mammary carcinomas and the influence of H-ras oncogene activation in female Sprague-Dawley rats. At 50 days of...

journal_title：Cancer letters

authors： Shirai K,Uemura Y,Fukumoto M,Tsukamoto T,Pascual R,Nandi S,Tsubura A

更新日期：1997-11-25 00:00:00

abstract：:The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

journal_title：Cancer letters

authors： Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

更新日期：1998-11-27 00:00:00

abstract：:We investigated the relative effectiveness of four differentiation-inducing chemicals to induce a more normal or benign phenotype in the human colon cancer cell lines Moser and HT29. The differentiation-inducing capability of all-trans retinoic acid (ATRA), difluoromethylornithine (DFMO), sodium butyrate (NaB) and sod...

journal_title：Cancer letters

authors： Reynolds S,Rajagopal S,Chakrabarty S

更新日期：1998-12-11 00:00:00

abstract：:Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated w...

journal_title：Cancer letters

authors： Jian Y,Wang M,Zhang Y,Ou R,Zhu Z,Ou Y,Chen X,Liang X,Ding Y,Song L,Xu X,Liao W

更新日期：2018-08-01 00:00:00

abstract：:The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

journal_title：Cancer letters

authors： Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

更新日期：2001-07-10 00:00:00

abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...

journal_title：Cancer letters

authors： Xu W,Chen GS,Shao Y,Li XL,Xu HC,Zhang H,Zhu GQ,Zhou YC,He XP,Sun WH

更新日期：2013-05-10 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00

abstract：:Nitric oxide synthase (NOS), an important bioregulator of a variety of biological processes, is overexpressed in colonic tumors of humans and rodents. In this study, effects of L-N(G)-nitroarginine methyl ester (L-NAME), a NOS inhibitor, on development of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in F344...

journal_title：Cancer letters

authors： Kawamori T,Takahashi M,Watanabe K,Ohta T,Nakatsugi S,Sugimura T,Wakabayashi K

更新日期：2000-01-01 00:00:00

abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

journal_title：Cancer letters

authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

更新日期：2002-12-10 00:00:00

abstract：:In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...

journal_title：Cancer letters

authors： Kong J,Ringer DP

更新日期：1996-08-02 00:00:00

abstract：:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

journal_title：Cancer letters

authors： Zhang L,Sun ZJ,Bian Y,Kulkarni AB

更新日期：2013-05-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

journal_title：Cancer letters

authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

更新日期：2011-12-26 00:00:00

abstract：:The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival wer...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V

更新日期：1996-12-20 00:00:00

abstract：:We investigated whether the level of bone marrow-derived progenitor cells and mature endothelial cells could be used as predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer. Peripheral blood mononuclear cells were obtained from 49 gastric cancer patients who rece...

journal_title：Cancer letters

authors： Shin SJ,Jeung HC,Ahn JB,Rha SY,Yoo NC,Roh JK,Noh SH,Chung HC

更新日期：2008-11-08 00:00:00

abstract：:A six-month bioassay in A/J mice was conducted to test the hypothesis that chronically inhaled mainstream cigarette smoke would either induce lung cancer or promote lung carcinogenicity induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Groups of 20 female A/J mice were ...

journal_title：Cancer letters

authors： Finch GL,Nikula KJ,Belinsky SA,Barr EB,Stoner GD,Lechner JF

更新日期：1996-02-06 00:00:00

abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...

journal_title：Cancer letters

authors： Sang M,Wang L,Ding C,Zhou X,Wang B,Wang L,Lian Y,Shan B

更新日期：2011-03-28 00:00:00

abstract：:Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites. Nucleic acid molecules are the important components of the EV cargo. Characterizing EVs and strategies for modulating the nucleic ac...

journal_title：Cancer letters

authors： Parayath NN,Padmakumar S,Amiji MM

更新日期：2020-07-10 00:00:00

abstract：:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...

journal_title：Cancer letters

authors： Wang YS,Tsang YW,Chi CH,Chang CC,Chu RM,Chi KH

更新日期：2008-08-08 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...

journal_title：Cancer letters

authors： Tang MK,Wong AS

更新日期：2015-10-10 00:00:00

abstract：:We generated three anti-ErbB-2 monoclonal antibodies (mAbs) by using surface-epitope masking method (SEM method). They were characterized and shown to recognize the extracellular domain (ECD) of ErbB-2 specifically. In order to detect ErbB-2 in the sera of breast cancer patients, we used two of them: A18 and A21 to de...

journal_title：Cancer letters

authors： Li P,Li Y,Li JY,Liu J

更新日期：2003-04-25 00:00:00

abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

journal_title：Cancer letters

authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

更新日期：2014-02-01 00:00:00

abstract：:The influence of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a mutagen in chlorinated water, on cell proliferation and lipid peroxidation in the glandular stomach mucosa was investigated in male 4-week-old Wistar rats. Animals were given 50 p.p.m., 25 p.p.m., 12.5 p.p.m., 6.25 p.p.m. or 0 p.p.m. of MX soluti...

journal_title：Cancer letters

authors： Nishikawa A,Kinae N,Furukawa F,Mitsui M,Enami T,Hasegawa T,Takahashi M

更新日期：1994-10-14 00:00:00

abstract：:YM529, a new third generation bisphosphonate, induced apoptosis of a human breast cancer cell line, MX-1. Cytotoxic activity of YM529 was more potent than that of incadronate. YM529 activated caspase-9, but not caspase-8, and induced the release of cytochrome c into cytosol. YM529 increased Bax expression and decrease...

journal_title：Cancer letters

authors： Nakajima H,Magae J,Tsuruga M,Sakaguchi K,Fujiwara I,Mizuta M,Sawai K,Yamagishi H,Mizuta N

更新日期：2007-08-08 00:00:00

abstract：:We constructed an SV40-derived expression vector containing a mutated albumin minigene of Nagase analbuminemic rats (NAR), and introduced it into cultured cells. Transient expression of the minigene mRNA was determined by RT-PCR. Three kinds of aberrant mRNAs were expressed by the non-hepatic cells COS-1, and the undi...

journal_title：Cancer letters

authors： Sugiyama K,Hitomi Y,Adachi H,Esumi H

更新日期：1994-08-15 00:00:00

abstract：:Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured c...

journal_title：Cancer letters

authors： Rho SB,Byun HJ,Park SY,Chun T

更新日期：2008-11-28 00:00:00

abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...

journal_title：Cancer letters

authors： Heston WD,Kadmon D,Fair WR

更新日期：1982-05-01 00:00:00

abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

journal_title：Cancer letters

authors： Jones MJ,Murray AW

更新日期：1983-05-01 00:00:00

abstract：:cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examin...

journal_title：Cancer letters

authors： Tanimoto T,Tsuda H,Imazeki N,Ohno Y,Imoto I,Inazawa J,Matsubara O

更新日期：2005-06-16 00:00:00