Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells.

abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...

journal_title：Cancer letters

authors： Sarkar D,Fisher PB

更新日期：2006-05-08 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...

journal_title：Cancer letters

authors： Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

更新日期：2016-06-01 00:00:00

abstract：:The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...

journal_title：Cancer letters

authors： Zhao Q,Yu X,Li M,Liu Y,Han Y,Zhang X,Li XM,Wu X,Qin J,Fang J,Zhang H

更新日期：2019-09-10 00:00:00

abstract：:This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mouse prostates due to ...

journal_title：Cancer letters

authors： Nikhil K,Chang L,Viccaro K,Jacobsen M,McGuire C,Satapathy SR,Tandiary M,Broman MM,Cresswell G,He YJ,Sandusky GE,Ratliff TL,Chowdhury D,Shah K

更新日期：2019-04-28 00:00:00

abstract：:Cell-adhesive protein laminin and its specific receptor play an important role in the processes of cancer proliferation, invasion and metastasis. In the present study, we cloned the cDNAs of the 67-kDa laminin receptor both from a human lung cell line (IMR90) and from a human lung cancer cell line (SBC3), and determin...

journal_title：Cancer letters

authors： Satoh K,Narumi K,Sakai T,Abe T,Kikuchi T,Matsushima K,Sindoh S,Motomiya M

更新日期：1992-03-15 00:00:00

abstract：:The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the a...

journal_title：Cancer letters

authors： Chmurzyńska W,Manteuffel-Cymborowska M,Sikora E,Grzelakowska-Sztabert B

更新日期：1984-12-01 00:00:00

abstract：:The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently...

journal_title：Cancer letters

authors： Zhang Y,Huang S,Dong W,Li L,Feng Y,Pan L,Han Z,Wang X,Ren G,Su D,Huang B,Lu J

更新日期：2009-05-08 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...

journal_title：Cancer letters

authors： Chiappini E,Berti E,Gianesin K,Petrara MR,Galli L,Giaquinto C,de Martino M,De Rossi A

更新日期：2014-05-28 00:00:00

abstract：:Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

journal_title：Cancer letters

authors： Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

更新日期：2002-01-25 00:00:00

abstract：:Fas/APO-1/CD95, a member of the tumor necrosis factor (TNF) receptor superfamily, is a potential anti-cancer factor as it can induce apoptosis in tumor cells. However, despite the fact that many cancer cells express Fas on the membrane, some tumors such as prostate cancer display resistance to Fas-induced apoptosis. I...

journal_title：Cancer letters

authors： Park IJ,Kim MJ,Park OJ,Park MG,Choe W,Kang I,Kim SS,Ha J

更新日期：2010-12-01 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...

journal_title：Cancer letters

authors： Chanda R,Ganguly AK

更新日期：1987-02-01 00:00:00

abstract：:Endometrial cancer is one of the most common gynecologic malignancies and many factors influence in its growth and development. As in many other types of cancer, prostaglandin E(2) (PGE(2)) is thought to be an accelerator of cell proliferation and endometrial cancer progression. In this study, we examined the effect o...

journal_title：Cancer letters

authors： Takahashi T,Ogawa H,Izumi K,Uehara H

更新日期：2011-07-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal tr...

journal_title：Cancer letters

authors： Hermonat PL

更新日期：1994-06-30 00:00:00

abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

journal_title：Cancer letters

authors： Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

更新日期：2013-07-01 00:00:00

abstract：:Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter...

journal_title：Cancer letters

authors： Richardson C

更新日期：2005-02-10 00:00:00

abstract：:Many of the polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene (B[a]P), benzanthracene (BA), 3-methylcholanthrene (3-MC)) are not only carcinogenic, but also induce AHH in human tissues. Recently, chrysene has been implicated as an etiologic determinant of chemical carcinogenesis. Here we describe the ability of c...

journal_title：Cancer letters

authors： Snodgrass DR,McLemore TL,Marshall MV,Wray NP,Cantrell ET,Busbee DL,Arnott MA

更新日期：1979-10-01 00:00:00

abstract：:Fumonisin B1 (FB1), a mycotoxin produced by a common corn contaminant Fusarium moniliforme and a hepatocarcinogen in rats, has been previously suggested to act as a poor initiator, but a better promoter of gamma-glutamyltranspeptidase (GGT)-positive rat liver preneoplastic lesions. Using glutathione S-transferase-plac...

journal_title：Cancer letters

authors： Mehta R,Lok E,Rowsell PR,Miller JD,Suzuki CA,Bondy GS

更新日期：1998-06-05 00:00:00

abstract：:It is widely known that dietary lipids can modify the ability of different cancers to grow up and metastasize, especially mammary gland tumors. However, it is still unclear whether n-6 fatty acids behave as tumor promoters in this gland cell population. The effect of different nutritional polyunsaturated fatty acids (...

journal_title：Cancer letters

authors： Muñoz SE,Lopez CB,Valentich MA,Eynard AR

更新日期：1998-04-24 00:00:00

abstract：:To obtain an optimal condition for ultrasound (US)-induced apoptosis that could be useful for cancer therapy, we applied low intensity pulsed US to sonicate U937 cells in vitro. Cells were then incubated at different time intervals before measuring apoptosis. The apoptosis was assessed by DNA fragmentation and phospha...

journal_title：Cancer letters

authors： Feril LB Jr,Kondo T,Cui ZG,Tabuchi Y,Zhao QL,Ando H,Misaki T,Yoshikawa H,Umemura S

更新日期：2005-04-28 00:00:00

abstract：:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...

journal_title：Cancer letters

authors： Manteuffel-Cymborowska M,Chmurzyńska W,Grzelakowska-Sztabert B

更新日期：1991-09-01 00:00:00

abstract：:The bmi-1 gene was identified as a common proviral integration site in Moloney murine leukemia virus. In the present studies, we cloned and sequenced the rat bmi-1 gene by reverse transcriptase-polymerase chain reaction (RT-PCR) using degenerate PCR primers of homologous sequences between mouse and human. We found 93%...

journal_title：Cancer letters

authors： Osaka M,Koami K,Sugiyama T

更新日期：1998-11-13 00:00:00

abstract：:Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metas...

journal_title：Cancer letters

authors： Tong D,Liu Q,Liu G,Xu J,Lan W,Jiang Y,Xiao H,Zhang D,Jiang J

更新日期：2017-03-28 00:00:00

abstract：:The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stabilit...

journal_title：Cancer letters

authors： Park SG,Min JY,Chung C,Hsieh A,Jung G

更新日期：2009-09-18 00:00:00

abstract：:NF-kappaB is activated in many types of cancer. Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8). Thus, inhibition of serine 276 phosphorylation may prevent metastasis and angiogen...

journal_title：Cancer letters

authors： Law M,Corsino P,Parker NT,Law BK

更新日期：2010-05-28 00:00:00

abstract：:Cachexia, also known as wasting syndrome notably with skeletal muscle atrophy, costs nearly one-third of all cancer deaths in man. (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenolic component in green tea, is a potent preventive against cachexia as well as cancers. However, how EGCG counteracts cachexia...

journal_title：Cancer letters

authors： Wang H,Lai YJ,Chan YL,Li TL,Wu CJ

更新日期：2011-06-01 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00

abstract：:In the present study a methodological approach is taken which quantitates aberrant dysplastic crypts in the unsectioned murine colon. C57BL/6J or CF1 female mice (7-8 weeks old) were injected (i.p.) with azoxymethane (5 mg/kg body wt./week) for 4 weeks. Their colons were excised, cut open on the median axis and fixed ...

journal_title：Cancer letters

authors： Bird RP

更新日期：1987-10-30 00:00:00

abstract：:We aimed to clarify the clinical significance of des-gamma-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC,...

journal_title：Cancer letters

authors： Shimada M,Yamashita Y,Hamatsu T,Hasegawa H,Utsunomiya T,Aishima S,Sugimachi K

更新日期：2000-10-16 00:00:00

abstract：:Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...

journal_title：Cancer letters

authors： Nigro ND,Campbell RL

更新日期：1978-08-01 00:00:00