Abstract:
:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal transduction initiation of cell growth. To study the potential regulation of these two prominent human proto-oncogenes by AAV, the expression of three marker coding sequences ligated 3' of the proto-oncogene promoters were observed. Demonstrated here, the AAV Rep78 gene product was able to down-regulate the human c-fos and c-myc proto-oncogene promoters in all three assay systems. These interactions may partially explain AAVs anti-proliferation properties.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hermonat PLdoi
10.1016/0304-3835(94)90193-7subject
Has Abstractpub_date
1994-06-30 00:00:00pages
129-36issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(94)90193-7journal_volume
81pub_type
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