Abstract:
:The (32)P-postlabelling method for the analysis of carcinogen-DNA adducts originated 30years ago from Baylor College of Medicine in Houston and was the work of a team comprised of Kurt and Erica Randerath, Ramesh Gupta and Vijay Reddy. With subsequent modifications and developments, it has become a highly sensitive and versatile method for the detection of DNA adducts that has been applied in a wide range of human, animal and in vitro studies. These include monitoring human exposure to environmental and occupational carcinogens, investigating genotoxicity of chemicals, elucidating pathways of metabolic activation of carcinogens, mechanistic studies of DNA repair, analysing the genotoxicity of complex mixtures and in ecotoxicology studies. Its use has been instrumental in providing new clues to the aetiology of some cancers and in identifying a new human carcinogen.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Phillips DHdoi
10.1016/j.canlet.2012.11.027subject
Has Abstractpub_date
2013-06-28 00:00:00pages
5-9issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(12)00685-4journal_volume
334pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract::Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.11.034
更新日期:2021-02-28 00:00:00
abstract::Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active di...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90138-y
更新日期:1993-02-01 00:00:00
abstract::Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00101-5
更新日期:2002-09-08 00:00:00
abstract::Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90147-3
更新日期:1994-07-15 00:00:00
abstract::Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.11.016
更新日期:2009-09-08 00:00:00
abstract::Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04503-x
更新日期:1997-01-01 00:00:00
abstract::Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We succes...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.12.025
更新日期:2016-03-01 00:00:00
abstract::Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00705-4
更新日期:2002-01-25 00:00:00
abstract::The first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. However, conclusive evidence that DNA viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when Epstein-Barr virus (EBV) was discov...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.05.010
更新日期:2007-03-18 00:00:00
abstract::Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.03.008
更新日期:2011-07-28 00:00:00
abstract::Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP3 correlate with each other. Herein, we demonstrated that c-Met expression in gastric cancer tissues significantly correlated wit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.12.040
更新日期:2012-06-01 00:00:00
abstract::Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/S0304-3835(03)00457-9
更新日期:2004-02-20 00:00:00
abstract::Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 homologs have been reported according to their sequence homology to the yeast Saccharomyces cerevisiae (Sc) Atg4. Accumulating evidence ha...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.01.022
更新日期:2016-04-01 00:00:00
abstract::The malignant phenotype results from multiple genetic alterations, including the activation of oncogenes and inactivation of tumor suppressor genes. Activation of the Ki-ras oncogene has been implicated as an early event in the pathogenesis of lung adenocarcinomas in humans and experimental animal models. Previous stu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00647-4
更新日期:2001-10-22 00:00:00
abstract::Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2004.11.065
更新日期:2005-10-18 00:00:00
abstract::Fanconi Anemia has recently been associated with a high risk of head and neck squamous cell carcinoma (HNSCC). Inactivation of the Fanconi Anemia (FANC-BRCA) pathway via promoter methylation of the FANCF gene has been proposed to be responsible for variation in cisplatinum (CDDP) sensitivity seen in ovarian and HNSCCs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.12.028
更新日期:2007-01-08 00:00:00
abstract::Chemotherapeutic multidrug resistance (MDR) is a significant challenge to overcome in clinic practice. Several mechanisms contribute to MDR, one of which is the augmented drug efflux induced by the upregulation of ABCB1 in cancer cells. Regorafenib, a multikinase inhibitor targeting the RAS/RAF/MEK/ERK pathway, was ap...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.03.011
更新日期:2017-06-28 00:00:00
abstract::A series of experiments was carried out to assess cytotoxic and cytogenetic effects in bone marrow polychromatic erythrocytes (PCE) and pulmonary alveolar macrophages (PAM) resulting from individual or combined exposure of male BD6 rats to ethanol, cigarette smoke and Aroclor 1254. Addition of 5% ethanol to drinking w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90127-u
更新日期:1993-08-31 00:00:00
abstract::Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.11.020
更新日期:2007-06-28 00:00:00
abstract::Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.03.029
更新日期:2004-09-15 00:00:00
abstract::Interferons are able to enhance the expression of carcinoembryonic antigen (CEA) on tumour cells, allowing improved tumour targeting. In this report the hypothesis is tested that combinations of cytokines may further increase the tumour antigen expression. The combination of both IFN-gamma and IFN-alpha with interleuk...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00007-5
更新日期:1999-05-03 00:00:00
abstract::We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.01.019
更新日期:2007-08-08 00:00:00
abstract::Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2. Here, we showed tha...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.002
更新日期:2015-02-01 00:00:00
abstract::We investigated the molecular effects of 3,4,2',4'-tetrahydroxychalcone (butein) treatment in two human hepatoma cancer cell lines-HepG2 and Hep3B. Butein treatment inhibited cancer cell growth by inducing G(2)/M phase arrest and apoptosis. Butein-induced G(2)/M phase arrest was associated with increased ATM, Chk1, an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.07.002
更新日期:2010-02-28 00:00:00
abstract::The time-dependent promotion activity of 17beta-estradiol (E2) by initiation with N-ethyl-N-nitrosourea (ENU) on induction of mouse uterine endometrial proliferative lesions was examined. Illumination-induced persistent estrous female CD-1 mice were divided into five groups at 9 weeks of age. At 10 weeks of age, mice ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00709-6
更新日期:2001-04-26 00:00:00
abstract::Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.12.020
更新日期:2014-04-28 00:00:00
abstract::Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA-DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA signif...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.02.021
更新日期:2006-02-08 00:00:00
abstract::We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly l...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00543-7
更新日期:2000-10-31 00:00:00
abstract::Changes in reduced folates upon exposure of Krebs ascites cells and L1210 murine leukemia cells to methotrexate (MTX) have been measured by stoichiometric entrapment of tissue methylenetetrahydrofolate into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2'-deoxy-uridine-5'-monophosphate. Tet...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90132-1
更新日期:1986-01-01 00:00:00
abstract::The effects of different sources of dietary protein, fat and carbohydrate on tumor development and on tests relating to cell-mediated immunity were investigated in male BALB/c mice after subcutaneous injection of 8 X 10(4) 1,2-dimethylhydrazine (DMH)-induced colon tumor (no. 51) cells. Results indicated that mice fed ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90117-9
更新日期:1983-02-01 00:00:00