In vitro upregulation of carcinoembryonic antigen expression by combinations of cytokines.

abstract：:Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimuri...

journal_title：Cancer letters

authors： Rubano DC,Teel RW,Strother A

更新日期：1990-07-16 00:00:00

abstract：:Fludarabine phosphate is a synthetic analog of beta-arabinofuranosyl adenine (beta-ara-A), an anti-viral agent. Since beta-ara-A has been shown to be an effective inhibitor of potentially lethal damage (PLD) repair in cell culture system but ineffective in in vivo tumors, we carried out experiments to determine whethe...

journal_title：Cancer letters

authors： Kim JH,Alfieri AA,Kim SH,Fuks Z

更新日期：1986-04-01 00:00:00

abstract：:These experiments were designed to test the role of the polyamine pathway in breast cancer progression utilizing an experimental system based on the development of ovary-independent rat mammary tumors and their sequential transplantation into syngeneic hosts. Three key enzymes involved in the PA biosynthetic/catabolic...

journal_title：Cancer letters

authors： Manni A,Grove R,Kunselman S,Aldaz CM

更新日期：1995-05-25 00:00:00

abstract：:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...

journal_title：Cancer letters

authors： Jiang W,Fujii H,Matsumoto T,Ohtsuji N,Tsurumaru M,Hino O

更新日期：2007-04-08 00:00:00

abstract：:A high-pressure liquid chromatographic (HPLC) method using a micro-particulate silica column and gradient elution was developed that separated 12-O-tetradecanoylphorbol-13-acetate (TPA) from 20-oxo-TPA; 12-O-tetradecanoylphorbol (TP); 13-O-acetylphorbol (PA), and from the diterpene alcohol, phorbol (P). A series of ot...

journal_title：Cancer letters

authors： Berry DL,Lieber MR,Fischer SM,Slaga TJ

更新日期：1977-09-01 00:00:00

abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...

journal_title：Cancer letters

authors： Tan W,Liao Y,Qiu Y,Liu H,Tan D,Wu T,Tang M,Zhang S,Wang H

更新日期：2018-08-01 00:00:00

abstract：:The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical staining showed that the COMT reaction in normal mammary tissue was restrict...

journal_title：Cancer letters

authors： Tenhunen J,Heikkilä P,Alanko A,Heinonen E,Akkila J,Ulmanen I

更新日期：1999-09-20 00:00:00

abstract：:Our aim was to identify novel tumor-associated antigens from the esophageal squamous cell carcinoma (ESCC) cell line EC0156, and related autoantibodies in sera from patients with ESCC. We used modified serological proteome analysis, involving one- and two-dimensional electrophoresis, Western blot, and MALDI-TOF/TOF-MS...

journal_title：Cancer letters

authors： Gao H,Zheng Z,Mao Y,Wang W,Qiao Y,Zhou L,Liu F,He H,Zhao X

更新日期：2014-03-01 00:00:00

abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...

journal_title：Cancer letters

authors： Ghosal A,Iba MM

更新日期：1990-09-01 00:00:00

abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...

journal_title：Cancer letters

authors： Mulder SE,Dasgupta A,King RJ,Abrego J,Attri KS,Murthy D,Shukla SK,Singh PK

更新日期：2020-10-28 00:00:00

abstract：:Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IG...

journal_title：Cancer letters

authors： Yao X,Wang Y,Duan Y,Zhang Q,Li P,Jin R,Tao Y,Zhang W,Wang X,Jing C,Zhou X

更新日期：2018-09-28 00:00:00

abstract：:The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...

journal_title：Cancer letters

authors： Keyler D,Pentel PR,Kuehl G,Collins G,Murphy SE

更新日期：2003-12-08 00:00:00

abstract：:BEC, a standard mixture of solasodine glycosides is effective in vivo against murine sarcoma 180 (S180), whereas the aglycone solasodine at equimolar concentrations is ineffective. The efficacy of BEC against S180 in vivo can be inhibited by rhamnose. Mice which are in their terminal stage with S180 can tolerate and b...

journal_title：Cancer letters

authors： Cham BE,Daunter B

更新日期：1990-12-17 00:00:00

abstract：:The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 ham...

journal_title：Cancer letters

authors： Nishikawa A,Furukawa F,Kasahara K,Tanakamaru Z,Miyauchi M,Nakamura H,Ikeda T,Imazawa T,Hirose M

更新日期：1999-07-01 00:00:00

abstract：:Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is associated with autophagy in regulating the chemosensitivity of HCC ce...

journal_title：Cancer letters

authors： Zhang N,Wu Y,Lyu X,Li B,Yan X,Xiong H,Li X,Huang G,Zeng Y,Zhang Y,Lian J,Ni Z,He F

更新日期：2017-11-28 00:00:00

abstract：:The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...

journal_title：Cancer letters

authors： Xu B,Guo X,Mathew S,Armesilla AL,Cassidy J,Darling JL,Wang W

更新日期：2010-05-28 00:00:00

abstract：:Endostatin has been demonstrated to represent a promising novel medicine to treat malignant tumors, and it may be more effective when combined with conventional treatment. Meanwhile, a promising area of research in radiation oncology is the integration of molecular targeting agents to improve the effectiveness of radi...

journal_title：Cancer letters

authors： Zhuang HQ,Yuan ZY

更新日期：2009-09-08 00:00:00

abstract：:The accumulation of the inducible hsp72 (72-kDa heat shock protein) after hyperthermia and/or cisplatin treatment in human glioblastoma cell line (A-172) was studied by Western blot analysis. The level of hsp72 increased to eight-fold 10 h after hyperthermia alone (44 degrees C for 20 min, D50) and to three-fold 10 h ...

journal_title：Cancer letters

authors： Matsumoto H,Hayashi S,Shioura H,Ohtsubo T,Ohnishi T,Kano E

更新日期：1996-12-20 00:00:00

abstract：:In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...

journal_title：Cancer letters

authors： Baghdiguian S,Boudier JA,Boudier JL,Fantini J

更新日期：1993-12-20 00:00:00

abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

journal_title：Cancer letters

authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

更新日期：1997-12-09 00:00:00

abstract：:Electron microscopic studies were made on an in vitro cultured cell line obtained from the FCB transplantable murine bladder tumour. The cells exhibited a loss of differentiation compared with solid tumour and the presence of C-type virus particles, many in the process of budding. The possible relation of this virus t...

journal_title：Cancer letters

authors： Flaks A

更新日期：1977-07-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...

journal_title：Cancer letters

authors： Lv W,Chen N,Lin Y,Ma H,Ruan Y,Li Z,Li X,Pan X,Tian X

更新日期：2016-06-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized end...

journal_title：Cancer letters

authors： Goto H,Matsuda K,Srikoon P,Kariya R,Hattori S,Taura M,Katano H,Okada S

更新日期：2013-05-01 00:00:00

abstract：:We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 phosphorylation which leads to inhibition of STAT3 phosphorylation. OPB-31121 inhibited constitutively activated and IL-6-i...

journal_title：Cancer letters

authors： Kim MJ,Nam HJ,Kim HP,Han SW,Im SA,Kim TY,Oh DY,Bang YJ

更新日期：2013-07-10 00:00:00

abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

journal_title：Cancer letters

authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

更新日期：1996-01-02 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood. Despite intensive multimodal therapy, nearly half of children with high-risk disease will relapse with therapy-resistant tumors. Dysregulation of MAPK pathway has been implicated in the pathogenesis of relapsed and refractory NB patient...

journal_title：Cancer letters

authors： Li H,Yu Y,Zhao Y,Wu D,Yu X,Lu J,Chen Z,Zhang H,Hu Y,Zhai Y,Su J,Aheman A,De Las Casas A,Jin J,Xu X,Shi Z,Woodfield SE,Vasudevan SA,Agarwal S,Yan Y,Yang J,Foster JH

更新日期：2019-08-10 00:00:00

abstract：:Hepatitis B virus (HBV) is a major etiologic agent of hepatocellular carcinoma (HCC). However, the molecular mechanism by which HBV infection contributes to HCC development is not fully understood. Here, we initially showed that HBV stimulates the production of cancer stem cells (CSCs)-related markers (CD133, CD117 an...

journal_title：Cancer letters

authors： Liu Z,Dai X,Wang T,Zhang C,Zhang W,Zhang W,Zhang Q,Wu K,Liu F,Liu Y,Wu J

更新日期：2017-08-01 00:00:00

abstract：:To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced by doxorubicin (DOX) delivered to human leukemia (HL-60) cells from pluronic P-105 micelles wi...

journal_title：Cancer letters

authors： Husseini GA,El-Fayoumi RI,O'Neill KL,Rapoport NY,Pitt WG

更新日期：2000-06-30 00:00:00

abstract：:The influence of grapefruit juice intake on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colon DNA damage was examined using comet assay in F344 rats given 60 mg/kg of PhIP by gavage. F344 rats allowed free access to grapefruit juice for 5 days experienced clearly reduced DNA damage in the colon to a...

journal_title：Cancer letters

authors： Miyata M,Takano H,Takahashi K,Sasaki YF,Yamazoe Y

更新日期：2002-09-08 00:00:00

abstract：:Although the concept of employing ultrasound for the treatment of cancer is not a new one, virtually all existing ultrasound-based clinical cancer treatments are based on hyperthermic ablation. This review seeks to highlight the potential offered by more subtle ultrasound-triggered phenomena such as sonoporation in de...

journal_title：Cancer letters

authors： Nomikou N,McHale AP

更新日期：2010-10-28 00:00:00