Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells.

abstract：:Mangiferin, a naturally occurring glucosylxanthone, was assessed for its immunomodulatory potential. The phytochemical induced extensive in vitro proliferation of murine splenocytes and thymocytes at the doses of 5-40 micrograms ml-1. Suppression of the proliferative response of the cells was observed with higher dose...

journal_title：Cancer letters

authors： Chattopadhyay U,Das S,Guha S,Ghosal S

更新日期：1987-11-01 00:00:00

abstract：:VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In v...

journal_title：Cancer letters

authors： Fuereder T,Jaeger-Lansky A,Hoeflmayer D,Preusser M,Strommer S,Cejka D,Koehrer S,Crevenna R,Wacheck V

更新日期：2010-10-28 00:00:00

abstract：:Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This f...

journal_title：Cancer letters

authors： Li X,Jiang L,Wang Y,Xiao Y,Huang Y,Yao Q,Yang Y,Wu X

更新日期：2007-10-18 00:00:00

abstract：:The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...

journal_title：Cancer letters

authors： Anastasiadou E,Vaeth S,Cuomo L,Boccellato F,Vincenti S,Cirone M,Presutti C,Junker S,Winberg G,Frati L,Wade PA,Faggioni A,Trivedi P

更新日期：2009-11-01 00:00:00

abstract：:Cell kinetics (cell proliferation and cell death) and the expression of progesterone receptor (PgR) during growth and regression of pregnancy-dependent mammary tumors (PDMT) of female GRS/A mice were investigated on the histologic level. Cell proliferation was determined using monoclonal anti-proliferating cell nuclea...

journal_title：Cancer letters

authors： Yang J,Senzaki H,Nambu H,Tsubura A

更新日期：1996-08-23 00:00:00

abstract：:Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...

journal_title：Cancer letters

authors： Lv D,Ma QH,Duan JJ,Wu HB,Zhao XL,Yu SC,Bian XW

更新日期：2016-07-10 00:00:00

abstract：:Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

journal_title：Cancer letters

authors： Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

更新日期：2019-07-01 00:00:00

abstract：:Loss of FHIT expression and p53 mutations are critical events in the early stages of lung carcinogenesis. The restoration of Fhit function in FHIT-negative cancer cells has been reported to cause tumour suppression by inhibition of cell proliferation and/or activation of apoptotic pathways. However, the studies design...

journal_title：Cancer letters

authors： Cavazzoni A,Galetti M,Fumarola C,Alfieri RR,Roz L,Andriani F,Carbognani P,Rusca M,Sozzi G,Petronini PG

更新日期：2007-02-08 00:00:00

abstract：:Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory ...

journal_title：Cancer letters

authors： Jiang D,Chen S,Sun R,Zhang X,Wang D

更新日期：2018-04-10 00:00:00

abstract：:This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...

journal_title：Cancer letters

authors： Onizawa K,Saginoya H,Furuya Y,Yoshida H

更新日期：1996-11-12 00:00:00

abstract：:In the last year, several evidences indicated that pharmacological manipulation of relevant signaling pathways could selectively affect gene expression to influence cell fate. These findings render of extreme importance the elucidation of how external stimuli are transduced to mediate chromatin modifications, resultin...

journal_title：Cancer letters

authors： Chiacchiera F,Simone C

更新日期：2008-06-28 00:00:00

abstract：:The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induc...

journal_title：Cancer letters

authors： Singh A,Singh SP,Bamezai R

更新日期：1998-01-09 00:00:00

abstract：:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

journal_title：Cancer letters

authors： Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

更新日期：2015-01-28 00:00:00

abstract：:Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence suggests that deregulation of TACC3 is associated with various types of human cancer. However, the molecular mechanisms by which TACC3 cont...

journal_title：Cancer letters

authors： Ha GH,Park JS,Breuer EK

更新日期：2013-05-10 00:00:00

abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

journal_title：Cancer letters

authors： Jones MJ,Murray AW

更新日期：1983-05-01 00:00:00

abstract：:We carried out a mutational analysis of BRCA1 and BRCA2 genes in 103 individuals from a population in Western Central Spain and we identified nine new variants: two truncating mutations in BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R], and fou...

journal_title：Cancer letters

authors： Salazar R,Cruz-Hernandez JJ,Sanchez-Valdivieso E,Rodriguez CA,Gomez-Bernal A,Barco E,Fonseca E,Portugal T,Gonzalez-Sarmiento R

更新日期：2006-02-20 00:00:00

abstract：:The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...

journal_title：Cancer letters

authors： Zhou A,Tang L,Zeng S,Lei Y,Yang S,Tang B

更新日期：2020-04-01 00:00:00

abstract：:Radiotherapy (RT) is one of the most important strategies in cancer treatment. Radioresistance is a major challenge to RT and results in locoregional recurrence and metastasis. Thus, there is a great interest in investigating biomarkers to distinguish radiosensitive from radioresistant (RR) cancer patients. The develo...

journal_title：Cancer letters

authors： Chang L,Graham P,Hao J,Bucci J,Malouf D,Gillatt D,Li Y

更新日期：2015-12-28 00:00:00

abstract：:R-spondins play critical roles in development, stem cell survival, and tumorigenicity by modulating Wnt/β-catenin signaling; however, the role of R-spondins in noncanonical Wnt signaling regulation remains largely unknown. We demonstrate here that R-spondin 2 (RSPO2) has an inhibitory effect on colorectal cancer (CRC)...

journal_title：Cancer letters

authors： Dong X,Liao W,Zhang L,Tu X,Hu J,Chen T,Dai X,Xiong Y,Liang W,Ding C,Liu R,Dai J,Wang O,Lu L,Lu X

更新日期：2017-08-28 00:00:00

abstract：:Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...

journal_title：Cancer letters

authors： Ulybina YM,Kuligina ES,Mitiushkina NV,Rozanov ME,Ivantsov AO,Ponomariova DN,Togo AV,Levchenko EV,Shutkin VA,Brenister SI,Devilee P,Zhivotovsky B,Hirvonen A,Imyanitov EN

更新日期：2009-06-18 00:00:00

abstract：:Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...

journal_title：Cancer letters

authors： Ramesh G,Das UN

更新日期：1998-01-30 00:00:00

abstract：:In the present study, we tested the hypothesis that a mild cerebral tissue injury promotes subsequent glioma invasion via activation of the ADAM17-EGFR-PI3K-Akt pathway. Mild injury was induced by photodynamic therapy (PDT), which employs tissue-penetrating laser light exposure following systemic administration of a t...

journal_title：Cancer letters

authors： Zheng X,Jiang F,Katakowski M,Zhang X,Jiang H,Zhang ZG,Chopp M

更新日期：2008-07-08 00:00:00

abstract：:The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can adapt to chemotherapy through a positive-feedback loop that favors chemoresistance. In platinum-resistant OC cells we ...

journal_title：Cancer letters

authors： Tocci P,Cianfrocca R,Sestito R,Rosanò L,Di Castro V,Blandino G,Bagnato A

更新日期：2020-11-01 00:00:00

abstract：:The effect of a methyl substituent at the non-benzo ring bay-region position of benzo[e]pyrene (B[e]P), cholanthrene (CA) and dibenz[a,j]anthracene (DB[a,j]A) on skin tumor-initiating activity was examined. A methyl substituent at the 1-carbon of B[e]P enhanced tumor-initiating activity of the parent compound (0.18 vs...

journal_title：Cancer letters

authors： Sawyer TW,Chang K,Harvey RG,DiGiovanni J

更新日期：1987-09-01 00:00:00

abstract：:Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...

journal_title：Cancer letters

authors： Dogra S,Bandi S,Viswanathan P,Gupta S

更新日期：2015-01-28 00:00:00

abstract：:The relative sensitivities of different tumor cells to photodynamic therapy (PDT) with benzoporphyrin derivative monoacid ring A (BPD-MA) were compared in the four tumor cells. A good correlation was observed between the cell survival at 0.1 microg/ml of BPD-MA and sensitizer uptake/10(6) cells (r = -0.99) or the plat...

journal_title：Cancer letters

authors： Osaki T,Takagi S,Hoshino Y,Okumura M,Fujinaga T

更新日期：2006-11-18 00:00:00

abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

journal_title：Cancer letters

authors： Parfett CL,Pilon R

更新日期：1993-07-30 00:00:00

abstract：:In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...

journal_title：Cancer letters

authors： Gratchev A,Siedow A,Bumke-Vogt C,Hummel M,Foss HD,Hanski ML,Kobalz U,Mann B,Lammert H,Mansmann U,Stein H,Riecken EO,Hanski C

更新日期：2001-07-10 00:00:00

abstract：:Fibronectin (FN), a heterodimeric glycoprotein overexpressed in several types of tumors, has been implicated in cancer progression via the activation of integrin-mediated pro-oncogenic pathways. The FN level in human bile fluid is dramatically increased in malignant biliary diseases; however, FN expression and its bio...

journal_title：Cancer letters

authors： Cao Y,Liu X,Lu W,Chen Y,Wu X,Li M,Wang XA,Zhang F,Jiang L,Zhang Y,Hu Y,Xiang S,Shu Y,Bao R,Li H,Wu W,Weng H,Yen Y,Liu Y

更新日期：2015-05-01 00:00:00

abstract：:In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cel...

journal_title：Cancer letters

authors： Leung LK,Do L,Wang TT

更新日期：1998-02-13 00:00:00