C-type virus particles in the transplantable mouse bladder tumour FCB grown in vitro.

abstract：:Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Hypoxia induces metabolic alterations in cancer, thereby promoting aggressive malignancy and metastasis. While previous efforts largely focused on adaptive responses in glucose and glutamine metabolism, recent studies have begun to yield i...

journal_title：Cancer letters

authors： Povero D,Johnson SM,Liu J

更新日期：2020-11-28 00:00:00

abstract：:Survivin, a novel antiapoptosis gene, was identified as a member of the inhibitor of apoptosis protein (IAP) family. Unique among IAP, survivin has been found to be abundantly expressed in a wide variety of human malignancies, whereas it is undetectable in normal adult tissues. Recently, three splicing variants of sur...

journal_title：Cancer letters

authors： Meng H,Lu C,Mabuchi H,Tanigawa N

更新日期：2004-12-28 00:00:00

abstract：:To investigate characteristic of lung adenocarcinoma growth behavior, we have established a cell line (rat lung cancer in Nara (RLCNR)) from a tumor induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in a rat. This clone shows an epithelial cell morphology and grows as sheets in culture with an approximate doubling t...

journal_title：Cancer letters

authors： Tsujiuchi T,Mori T,Amanuma T,Tanaka N,Tsutsumi M

更新日期：2005-01-10 00:00:00

abstract：:Glypican-5 (GPC5) may be a potential tumor suppressor gene in non-small cell lung cancer (NSCLC). The present study aimed to clarify the GPC5 expression pattern and to explore its potential functions in NSCLC. The expression of GPC5 gene was lower in lung cancer tissues compared with adjacent noncancerous tissues. The...

journal_title：Cancer letters

authors： Yang X,Zhang Z,Qiu M,Hu J,Fan X,Wang J,Xu L,Yin R

更新日期：2013-12-01 00:00:00

abstract：:Doxorubicin (dox) is an anthracycline antibiotic which is broadly used in solid tumors. Long-term therapy with this drug is accompanied by potentially lethal, dose-dependent side effects. Several reports suggest that oxygen free radicals produced during the metabolic activation of dox may have toxic effects on heart m...

journal_title：Cancer letters

authors： Kozluca O,Olcay E,Sürücü S,Güran Z,Kulaksiz T,Uskent N

更新日期：1996-01-19 00:00:00

abstract：:The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...

journal_title：Cancer letters

authors： Mikol YB,Poirier LA

更新日期：1981-08-01 00:00:00

abstract：:The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...

journal_title：Cancer letters

authors： Begum A,Kim Y,Lin Q,Yun Z

更新日期：2012-05-01 00:00:00

abstract：:Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung cancer (NSCLC) and identified the specific molecules involved. We identif...

journal_title：Cancer letters

authors： Kim DH,Park S,Kim H,Choi YJ,Kim SY,Sung KJ,Sung YH,Choi CM,Yun M,Yi YS,Lee CW,Kim SY,Lee JC,Rho JK

更新日期：2020-04-10 00:00:00

abstract：:The suitability of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay to the determination of cell viability following photoradiation therapy (PRT) of human breast and melanoma cell lines has been examined. Results have been shown to correlate with those obtained using a clonogen...

journal_title：Cancer letters

authors： McHale AP,McHale L

更新日期：1988-08-30 00:00:00

abstract：:To assess the putative role of extracellular matrix (ECM) proteins on lung cells interacting with integrin receptors on colon carcinoma cells, an in vitro adhesion assay was used to investigate these factors. Tumor necrosis factor (TNF)-alpha treatment of fetal lung cell line MRC 9, upregulated expression of ECM prote...

journal_title：Cancer letters

authors： Karmakar S,Mukherjee R

更新日期：2003-07-10 00:00:00

abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...

journal_title：Cancer letters

authors： Shukla Y,Antony M,Mehrotra NK

更新日期：1992-02-29 00:00:00

abstract：:The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to "reactive resistance" to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for ...

journal_title：Cancer letters

authors： Li Y,Cai B,Shen L,Dong Y,Lu Q,Sun S,Liu S,Ma S,Ma PX,Chen J

更新日期：2017-07-01 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP), which hydrolyzes type I collagen and activates MMP-2, are deeply involved in angiogenesis as well as in tumor cell invasion and metastasis. We previously screened a number of natural and synthetic compounds to obtain a specific inhibitor of MT1-MMP and observed that ...

journal_title：Cancer letters

authors： Yamakawa S,Asai T,Uchida T,Matsukawa M,Akizawa T,Oku N

更新日期：2004-07-08 00:00:00

abstract：:The molecular chaperone Hsp90 is not only of major current interest in fundamental biological research but also recognised as an exciting new target for the treatment of cancer and other diseases. In addition to playing an important role in response to proteotoxic heat shock and others stresses, Hsp90 is also critical...

journal_title：Cancer letters

authors： Workman P

更新日期：2004-04-08 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...

journal_title：Cancer letters

authors： Schut HA,Herzog CR

更新日期：1992-12-24 00:00:00

abstract：:Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...

journal_title：Cancer letters

authors： Zahniser DJ,Isenstein LM,Hutchinson ML

更新日期：1994-03-15 00:00:00

abstract：:The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in ...

journal_title：Cancer letters

authors： Zavanella T,Zaffaroni NP,Arias E

更新日期：1980-08-01 00:00:00

abstract：:Lectins are suitable tools for investigating the glycoconjugate characteristics of metastatic cells. In the present study, we investigated whether there were differences between high metastatic T3 cells and a low metastatic isolate in their reactivities to several lectins specific for galactosyl and sialyl groups. Ana...

journal_title：Cancer letters

authors： Mannori G,Mugnai G,Ruggieri S

更新日期：1991-08-01 00:00:00

abstract：:The effect of dietary intake of an extract of the spice plant Rosmarinus officinalis L. on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and on the in vivo formation of mammary DMBA-DNA adducts was evaluated. Supplementation of a semi-purified diet with 1.0% (by wt.) rosemary extract resulted in ...

journal_title：Cancer letters

authors： Singletary KW,Nelshoppen JM

更新日期：1991-11-01 00:00:00

abstract：:Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP3 correlate with each other. Herein, we demonstrated that c-Met expression in gastric cancer tissues significantly correlated wit...

journal_title：Cancer letters

authors： Wang J,Gui Z,Deng L,Sun M,Guo R,Zhang W,Shen L

更新日期：2012-06-01 00:00:00

abstract：:Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotox...

journal_title：Cancer letters

authors： Choy YM,Cheng CP,Luey LU,Loh SC,Fung KP,Lee CY

更新日期：1987-10-01 00:00:00

abstract：:Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been considered as a potential therapeutic problem. In the stressful microenvironment condition, hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a central player for the...

journal_title：Cancer letters

authors： Kim YH,Yoo KC,Cui YH,Uddin N,Lim EJ,Kim MJ,Nam SY,Kim IG,Suh Y,Lee SJ

更新日期：2014-11-01 00:00:00

abstract：:The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...

journal_title：Cancer letters

authors： Brown RC,Poole A,Fleming GT

更新日期：1983-03-01 00:00:00

abstract：:The concept of metronomic chemotherapy (MC) has evolved from a descriptive preclinical phenomenon encompassing inhibition of angiogenesis to a clinically validated treatment concept involving multiple potential mechanisms of action. Clinicians are progressively more incline to consider MC as a component of mainstream ...

journal_title：Cancer letters

authors： Munzone E,Colleoni M

更新日期：2017-08-01 00:00:00

abstract：:Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACT...

journal_title：Cancer letters

authors： Li LB,Louie MC,Chen HW,Zou JX

更新日期：2008-03-08 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible for chemoresistance and metastasis. In this study, we identify LRP8 as...

journal_title：Cancer letters

authors： Lin CC,Lo MC,Moody R,Jiang H,Harouaka R,Stevers N,Tinsley S,Gasparyan M,Wicha M,Sun D

更新日期：2018-12-01 00:00:00

abstract：:To determine Toxoplasma gondii antibodies in cancer patients, 267 cancer patients were studied using ELISA and higher positivity rates of T. gondii IgG were detected than the control. The positivity rates of T. gondii IgG in nasopharyngeal carcinoma, rectal cancer groups were significantly higher than the other cancer...

journal_title：Cancer letters

authors： Yuan Z,Gao S,Liu Q,Xia X,Liu X,Liu B,Hu R

更新日期：2007-08-28 00:00:00

abstract：:Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

journal_title：Cancer letters

authors： Devens BH,Lundak RL,Byus CV

更新日期：1984-01-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...

journal_title：Cancer letters

authors： Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM

更新日期：2016-05-01 00:00:00

abstract：:A 1-week treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) induces the appearance of preneoplastic liver lesions--oval cell hyperplasia, basophilic and gamma-glutamyltranspeptidase positive (GGT+) foci--in female Wistar rats, as evidenced by the ...

journal_title：Cancer letters

authors： Zavanella T,Presta M,Braga G,Dimito E,Mazzocchi C,Ziliani S,Ragnotti G

更新日期：1984-11-01 00:00:00