Abstract:
:Lectins are suitable tools for investigating the glycoconjugate characteristics of metastatic cells. In the present study, we investigated whether there were differences between high metastatic T3 cells and a low metastatic isolate in their reactivities to several lectins specific for galactosyl and sialyl groups. Analysis of reactivity of the two cell lines to wheat germ agglutinin revealed a complex pattern. In fact, T3 cells had high-affinity, neuraminidase-resistant as well as low-affinity, neuraminidase-sensitive receptors. Instead, the low metastatic isolate showed only high-affinity receptors, both neuraminidase-resistant and neuraminidase-sensitive The two cell lines reacted similarly to galactose-specific lectins. These findings indicate that sialyl groups, rather than galactosyl groups, affect the metastatic behavior of our cell system.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Mannori G,Mugnai G,Ruggieri Sdoi
10.1016/0304-3835(91)90177-jsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
133-8issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(91)90177-Jjournal_volume
59pub_type
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