Abstract：
:Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm2) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); we also found that serum deprivation during cell culture induced the expression of IFN-β and TRAIL. In addition, the mRNA expression of IFN-β, but not TRAIL, was increased during the washing step required for the transplantation of normal-density (5000 cells/cm2) cultured ASCs (5K-ASCs). When the human lung cancer cell line H460 was co-cultured with 40K-ASCs, necrotic cell death was dramatically increased in vitro. When ASCs were injected after four washes, both 5K-ASCs and 40K-ASCs substantially reduced tumor weight in H460-derived cancer animal models. These results suggest that serum deprivation during the culture of 40K-ASCs or during the washing step of 5K-ASCs can induce IFN-β and/or TRAIL expression, ultimately leading to the tumor suppression capability of ASCs.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jung PY,Ryu H,Rhee KJ,Hwang S,Lee CG,Gwon SY,Kim J,Kim J,Yoo BS,Baik SK,Bae KS,Eom YWdoi
10.1016/j.canlet.2018.10.017subject
Has Abstractpub_date
2019-01-01 00:00:00pages
202-210eissn
0304-3835issn
1872-7980pii
S0304-3835(18)30631-1journal_volume
440-441pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04407-2
更新日期：1996-10-01 00:00:00
abstract：:The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03688-s
更新日期：1995-03-02 00:00:00
abstract：:Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.10.030
更新日期：2004-03-08 00:00:00
abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.04.009
更新日期：2006-05-08 00:00:00
abstract：:In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cel...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00430-8
更新日期：1998-02-13 00:00:00
abstract：:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.08.008
更新日期：2010-12-28 00:00:00
abstract：:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90147-a
更新日期：1991-09-01 00:00:00
abstract：:Starting with an extract derived from the bark of Mundulea sericea Willd. (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00309-7
更新日期：1999-02-08 00:00:00
abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.02.023
更新日期：2017-05-28 00:00:00
abstract：:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00171-2
更新日期：1998-10-23 00:00:00
abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.014
更新日期：2014-08-28 00:00:00
abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.07.008
更新日期：2019-10-01 00:00:00
abstract：:The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90033-6
更新日期：1980-08-01 00:00:00
abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.12.030
更新日期：2013-05-10 00:00:00
abstract：:Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90023-1
更新日期：1987-09-01 00:00:00
abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.01.001
更新日期：2008-05-18 00:00:00
abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90141-6
更新日期：1983-05-01 00:00:00
abstract：:Under most circumstances, hepatitis B virus (HBV) is noncytopathic. However, hepatocellular regeneration that accompanies each bout of hepatitis appears to be associated with increased integration of HBV DNA fragments expressing the virus encoded hepatitis B x antigen (HBxAg). Intrahepatic HBxAg staining correlates wi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.12.010
更新日期：2009-12-01 00:00:00
abstract：:When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90072-4
更新日期：1989-06-01 00:00:00
abstract：:The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects o...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.12.037
更新日期：2018-03-28 00:00:00
abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90159-u
更新日期：1990-03-01 00:00:00
abstract：:Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown that POLD2 plays a critical role in DNA replication, DNA repair and genomic stability. We demonstrate for the first time that POLD2 is highly exp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.01.011
更新日期：2020-07-10 00:00:00
abstract：:Citral inhibits the formation of retinoic acid from retinol in mouse epidermis. Since skin-carcinogenesis is sensitive to retinoid status, and retinoic acid may be the active form of vitamin A in the epidermis, citral was tested for its ability to modulate tumor promotion in a two-stage skin-carcinogenesis study in ha...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90189-o
更新日期：1991-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.08.027
更新日期：2020-12-01 00:00:00
abstract：:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03836-l
更新日期：1995-07-20 00:00:00
abstract：:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04164-x
更新日期：1996-04-19 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.05.018
更新日期：2007-04-08 00:00:00
abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.03.010
更新日期：2008-08-18 00:00:00
abstract：:RXRalpha is an obligatory heterodimerization partner in many signal transducing pathways. To evaluate RXRalpha expression during laryngeal carcinogenesis, immunohistochemistry was performed on laryngeal epithelial specimens of 154 patients with normal-appearing, hyperplastic, dysplastic laryngeal epithelium and squamo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00346-x
更新日期：2003-09-25 00:00:00
abstract：:This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and u...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.09.033
更新日期：2005-05-10 00:00:00
