当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Time-dependent promotion activity of 17beta-estradiol on uterine carcinogenesis in mice initiated with N-ethyl-N-nitrosourea.

Time-dependent promotion activity of 17beta-estradiol on uterine carcinogenesis in mice initiated with N-ethyl-N-nitrosourea.

Abstract：

:The time-dependent promotion activity of 17beta-estradiol (E2) by initiation with N-ethyl-N-nitrosourea (ENU) on induction of mouse uterine endometrial proliferative lesions was examined. Illumination-induced persistent estrous female CD-1 mice were divided into five groups at 9 weeks of age. At 10 weeks of age, mice in all groups (n=25) were given a single intra-uterine administration of ENU (50 mg/kg), dissolved in polyethylene glycol. Animals in Groups 2 to 5 were then implanted s.c. with an E2 pellet at 9, 11, 14 and 17 weeks of age. The implants were left in place for 8 weeks and then taken out. At the termination of the experiment (week 15 after the ENU-treatment), all surviving mice were killed and the development of uterine proliferative lesions were assessed. All groups demonstrated endometrial hyperplasias and adenocarcinomas and the incidences of the latter in ENU plus E2 treated animals (Groups 2 to 5; 36, 48, 35 and 36%, respectively) were significantly higher compared to 8% for Group 1, without any variation with the age at E2 treatment. However, the incidences of adenocarcinomas plus severe hyperplasias increased from Groups 1 to 5 (28, 40, 56; P<0.05, 61; P<0.05 and 80%; P<0.01, respectively), indicating that promotion effects of E2 on induction of uterine proliferative lesions in the uterine endometrium become more pronounced with the interval after ENU initiation.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Takahashi M,Nishimura S,Miyajima K,Sasahara K,Yoshida M,Ando J,Maekawa A

doi

10.1016/s0304-3835(00)00709-6

keywords:

subject

Has Abstract

pub_date

2001-04-26 00:00:00

pages

123-30

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383500007096

journal_volume

165

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Differential nuclear matrix-intermediate filament expression in human prostate cancer in respect to benign prostatic hyperplasia.

    abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04444-8

    authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

    更新日期：1996-12-03 00:00:00

  • The field bean protease inhibitor has the potential to suppress B16F10 melanoma cell lung metastasis in mice.

    abstract：:Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00090-1

    authors： Banerji A,Fernandes A,Bane S,Ahire S

    更新日期：1998-07-03 00:00:00

  • The toxicity of anti-VEGF agents when coupled with standard chemotherapeutics.

    abstract：:Bevacizumab (Avastin®, Genentech, CA) was granted accelerated approval by the FDA for metastatic breast cancer in 2008. This occurred after the initial clinical trial, E2100, demonstrated an improvement in progression-free survival (PFS) and overall survival (OS) with the addition of bevacizumab to a standard chemothe...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.10.028

    authors： Afranie-Sakyi JA,Klement GL

    更新日期：2015-02-01 00:00:00

  • Relationships between oestrogen-inducible proteins, oestradiol and electrolyte ratio in breast cyst fluid.

    abstract：:Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were fo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90027-7

    authors： Lai LC,Cornell C,Lennard TW

    更新日期：1993-04-15 00:00:00

  • Growth inhibition of a prostate tumor by alpha-difluoromethylornithine and by cyclophosphamide.

    abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90093-3

    authors： Heston WD,Kadmon D,Fair WR

    更新日期：1982-05-01 00:00:00

  • A short peptide derived from the gN helix domain of FGF8b suppresses the growth of human prostate cancer cells.

    abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.06.001

    authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

    更新日期：2013-10-10 00:00:00

  • Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: a serum proteomic approach using mass spectrometry.

    abstract：:Adult T-cell leukemia (ATL) is a fatal malignancy caused by infection with human T lymphotropic virus type-1 (HTLV-1). To search for a new biomarker of ATL, we analyzed sera from ATL patients using ProteinChip arrays. The spectral comparison of ATL patients with HTLV-1 carriers and healthy volunteers showed that the i...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.06.004

    authors： Ishida Y,Yamashita K,Sasaki H,Takajou I,Kubuki Y,Morishita K,Tsubouchi H,Okayama A

    更新日期：2008-11-18 00:00:00

  • Induction of Plac8 promotes pro-survival function of autophagy in cadmium-induced prostate carcinogenesis.

    abstract：:Chronic exposure to cadmium is known to be a risk factor for human prostate cancer. Despite over-whelming evidence of cadmium causing carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal-induced cellular transformation remain unclear. Acute exposure (up to 72 h) to cadmium induces ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.08.023

    authors： Kolluru V,Pal D,Papu John AMS,Ankem MK,Freedman JH,Damodaran C

    更新日期：2017-11-01 00:00:00

  • Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.

    abstract：:Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in diverse biological activities such as DNA replication, transcription, recombination and repair. Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes char...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2017.10.021

    authors： Mo D,Zhao Y,Balajee AS

    更新日期：2018-01-28 00:00:00

  • Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.

    abstract：:The effect of a methyl substituent at the non-benzo ring bay-region position of benzo[e]pyrene (B[e]P), cholanthrene (CA) and dibenz[a,j]anthracene (DB[a,j]A) on skin tumor-initiating activity was examined. A methyl substituent at the 1-carbon of B[e]P enhanced tumor-initiating activity of the parent compound (0.18 vs...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90025-5

    authors： Sawyer TW,Chang K,Harvey RG,DiGiovanni J

    更新日期：1987-09-01 00:00:00

  • MCF-7 breast cancer cell line grown in agarose culture for study of COX-2 inhibitors in three-dimensional growth system.

    abstract：:Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.10.030

    authors： Kinder DH,Aulthouse AL

    更新日期：2004-03-08 00:00:00

  • Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

    abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00147-0

    authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

    更新日期：1999-07-19 00:00:00

  • Experimental hypoxia is a potent stimulus for radiotracer uptake in vitro: comparison of different tumor cells and primary endothelial cells.

    abstract：:Hypoxia causes upregulation of vascular endothelial growth factor (VEGF) which is a key regulator in tumor angiogenesis and essential for the proliferation of endothelial cells. Endothelial cells have been described to accumulate radiotracers like (18)F-FDG. However, the contribution of radiotracer uptake by endotheli...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.02.016

    authors： Oswald J,Treite F,Haase C,Kampfrath T,Mäding P,Schwenzer B,Bergmann R,Pietzsch J

    更新日期：2007-08-28 00:00:00

  • Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.

    abstract：:d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, wh...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90097-3

    authors： Torelli S,Masoudi F,Prasad KN

    更新日期：1988-03-01 00:00:00

  • Chromosomal end-to-end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit.

    abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.08.028

    authors： Rebuzzini P,Lisa A,Giulotto E,Mondello C

    更新日期：2004-01-08 00:00:00

  • p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.

    abstract：:The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.11.034

    authors： Adachi S,Natsume H,Yamauchi J,Matsushima-Nishiwaki R,Joe AK,Moriwaki H,Kozawa O

    更新日期：2009-05-08 00:00:00

  • Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters.

    abstract：:The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.01.021

    authors： Fan YF,Zhang W,Zeng L,Lei ZN,Cai CY,Gupta P,Yang DH,Cui Q,Qin ZD,Chen ZS,Trombetta LD

    更新日期：2018-05-01 00:00:00

  • Rectal epithelial proliferation characteristics of first degree relatives of sporadic colon cancer patients.

    abstract：:Hyperproliferation of rectal epithelium is characteristic of families at high genetic risk for large bowel neoplasia, but has not been well-documented in families of sporadic colorectal cancer patients. This was studied in 119 such first degree relatives and 44 comparison subjects without this family history. All scre...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90047-2

    authors： Rozen P,Fireman Z,Fine N,Chetrit A,Lubin F

    更新日期：1990-05-30 00:00:00

  • The microcirculation in two transplantable melanomas of the hamster. I. In vivo observations in transparent chambers.

    abstract：:Twenty-eight transparent chambers were inserted into the cheek pouches of hamsters and daily serial observations made of the changing vasculature of transplants of 2 varieties (A-Mel-4B32, ZGYP1) of amelanotic melanomas. The tumor A-Mel-4B32 grew at a rate which covered 50% of the viewing area in 3--4 days, while the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)93797-7

    authors： Warren BA,Shubik P,Wilson R,Garcia H,Feldman R

    更新日期：1978-02-01 00:00:00

  • Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.

    abstract：:The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.10.013

    authors： Xu B,Guo X,Mathew S,Armesilla AL,Cassidy J,Darling JL,Wang W

    更新日期：2010-05-28 00:00:00

  • Cationic liposomes enhance retrovirus-mediated multinucleated cell formation and retroviral transduction.

    abstract：:A retroviral vector carrying herpes simplex virus thymidine kinase (HSV-TK) gene was introduced into psi 2 packaging cells (psi 2tkn) and XC tumor cells (XCtkn). psi 2tkn, XCtkn and XC cells co-cultured with TK-carrying cells were killed by ganciclovir (GCV) treatment. The growth of XC cells transplanted into nude mic...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04260-7

    authors： Kaneko Y,Tsukamoto A

    更新日期：1996-07-19 00:00:00

  • Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia.

    abstract：:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90250-2

    authors： Bybee A,Styles JA,Beck SL,Blackburn D

    更新日期：1990-07-16 00:00:00

  • Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor.

    abstract：:Nitric oxide synthase (NOS), an important bioregulator of a variety of biological processes, is overexpressed in colonic tumors of humans and rodents. In this study, effects of L-N(G)-nitroarginine methyl ester (L-NAME), a NOS inhibitor, on development of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in F344...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00310-9

    authors： Kawamori T,Takahashi M,Watanabe K,Ohta T,Nakatsugi S,Sugimura T,Wakabayashi K

    更新日期：2000-01-01 00:00:00

  • Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.

    abstract：:Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90023-4

    authors： Wong LM,Bern HA,Jones LA,Mills KT

    更新日期：1982-11-01 00:00:00

  • Tri-n-butyltin chloride promotes morphological transformation and induces proliferin expression in C3H10T1/2 cells.

    abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90112-m

    authors： Parfett CL,Pilon R

    更新日期：1993-07-30 00:00:00

  • Aromatase induction in tamoxifen-resistant breast cancer: Role of phosphoinositide 3-kinase-dependent CREB activation.

    abstract：:Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.05.003

    authors： Phuong NT,Lim SC,Kim YM,Kang KW

    更新日期：2014-08-28 00:00:00

  • Comparative metabolism and macromolecular binding of benzo[a]pyrene in explant cultures of human bladder, skin, bronchus and esophagus from eight individuals.

    abstract：:Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90112-x

    authors： Selkirk JK,Nikbakht A,Stoner GD

    更新日期：1983-02-01 00:00:00

  • Feasibility of using lower doses of chemopreventive agents in a combination regimen for cancer protection.

    abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90066-3

    authors： Ip C

    更新日期：1988-04-01 00:00:00

  • The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients.

    abstract：:Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.11.029

    authors： Spanier G,Ugele I,Nieberle F,Symeou L,Schmidhofer S,Brand A,Meier J,Spoerl S,Krupar R,Rümmele P,Siska P,Renner K,Peter K,Gerken M,Beckhove P,Reichert TE,Kreutz M,Singer K

    更新日期：2021-02-28 00:00:00

  • Anti-angiogenesis therapy in cancer: current challenges and future perspectives.

    abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2012.03.008

    authors： Shojaei F

    更新日期：2012-07-28 00:00:00