Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.

Abstract:

:Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganized in all neonatally estrogenized groups with age, the later estrogen treatment reduced the incidence and severity of vaginal epithelial lesions and the incidence of vaginal concretions. Uterine epithelial metaplasia was accelerated by the later estrogen treatment.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Wong LM,Bern HA,Jones LA,Mills KT

doi

10.1016/0304-3835(82)90023-4

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

115-23

issue

2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(82)90023-4

journal_volume

17

pub_type

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