Abstract：
:Hyperproliferation of rectal epithelium is characteristic of families at high genetic risk for large bowel neoplasia, but has not been well-documented in families of sporadic colorectal cancer patients. This was studied in 119 such first degree relatives and 44 comparison subjects without this family history. All screened negative for large bowel neoplasia. Within the family group proliferation was significantly higher in the men and those aged less than 45 years, also higher (insignificantly) in non-Europeans and those having greater than 1 first degree colorectal cancer relative. In comparison to the nonfamily group the labelling index (LI) of the relatives showed a significant negative correlation with age (R = -0.20, P = 0.03). Within this family group the probability of having an elevated LI (greater than 6.0%) was greatest in the young (less than 50 years old) men (odds ratio = 2.0). Measurements of rectal epithelial proliferation (REP) in these first degree relatives, at a young age, might help delineate a high risk subgroup for prospective primary and secondary intervention.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Rozen P,Fireman Z,Fine N,Chetrit A,Lubin Fdoi
10.1016/0304-3835(90)90047-2subject
Has Abstractpub_date
1990-05-30 00:00:00pages
127-32issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(90)90047-2journal_volume
51pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90130-8
更新日期：1986-01-01 00:00:00
abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.01.006
更新日期：2012-06-28 00:00:00
abstract：:Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this dis...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.01.032
更新日期：2015-01-28 00:00:00
abstract：:Despite the significance of tumor angiogenesis and the extensive knowledge on the molecular basis of blood vessel formation in carcinoma of colorectum, no data exist in hyperplastic polyp. This prompted us to examine angiogenesis in hyperplastic polyp. Eleven small hyperplastic polyps, 13 large hyperplastic polyps and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/S0304-3835(03)00183-6
更新日期：2005-02-10 00:00:00
abstract：:A retroviral vector carrying herpes simplex virus thymidine kinase (HSV-TK) gene was introduced into psi 2 packaging cells (psi 2tkn) and XC tumor cells (XCtkn). psi 2tkn, XCtkn and XC cells co-cultured with TK-carrying cells were killed by ganciclovir (GCV) treatment. The growth of XC cells transplanted into nude mic...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04260-7
更新日期：1996-07-19 00:00:00
abstract：:TGF-β signaling plays an important role in breast cancer progression and metastasis. Epithelial-mesenchymal transition (EMT) is an important step in the progression of solid tumors to metastatic disease. We previously reported that IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.006
更新日期：2014-08-28 00:00:00
abstract：:BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. W...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00845-x
更新日期：2002-11-08 00:00:00
abstract：:Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 homologs have been reported according to their sequence homology to the yeast Saccharomyces cerevisiae (Sc) Atg4. Accumulating evidence ha...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.01.022
更新日期：2016-04-01 00:00:00
abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90039-9
更新日期：1984-02-01 00:00:00
abstract：:Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(81)90047-1
更新日期：1981-03-01 00:00:00
abstract：:The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80075-0
更新日期：1979-06-01 00:00:00
abstract：:Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90189-1
更新日期：1983-08-01 00:00:00
abstract：:Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.11.016
更新日期：2009-09-08 00:00:00
abstract：:To clarify the detailed molecular mechanism underlying cellular responses to nonthermal low-intensity pulsed ultrasound (LIPUS), gene expression patterns and genetic networks in human lymphoma U937 cells were examined using global-scale microarrays and computational gene expression analysis tools. Six hours after LIPU...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.05.018
更新日期：2008-11-08 00:00:00
abstract：:Nitric oxide (NO) and associated reactive nitrogen species (RNS) are involved in many physiological functions. There has been an ongoing debate to whether RNS can inhibit or perpetuate chronic inflammation and associated carcinogenesis. Although the final outcome depends on the genetic make-up of its target, the surro...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.03.024
更新日期：2008-09-08 00:00:00
abstract：:Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats rece...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.09.011
更新日期：2006-08-28 00:00:00
abstract：:Previously, we have shown that dietary retinoic acid (RA) at pharmacological doses (30 micrograms/g of diet) inhibited the malignant conversion of skin papillomas to carcinomas induced by a two-stage carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA)...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90032-9
更新日期：1994-04-01 00:00:00
abstract：:Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2004.11.065
更新日期：2005-10-18 00:00:00
abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)04078-1
更新日期：1996-02-27 00:00:00
abstract：:Acquired resistance to mechanisms of programmed cell death is one of the hallmarks of cancer. Human melanoma, in advanced stage, is hardly curable, due to development of several strategies that impair apoptosis induced by the death receptor and the mitochondrial pathways of apoptosis. Among these apoptosis escape stra...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.06.034
更新日期：2006-07-18 00:00:00
abstract：:Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80090-7
更新日期：1979-05-01 00:00:00
abstract：:This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known antidepressant fluoxetine (prozac). The MDR phenomena and mechanisms are discussed, including the roles of ABC transporters as MDR-pumps and the potential involvement of cancer stem cells. The three ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.06.003
更新日期：2006-06-18 00:00:00
abstract：:Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is associated with autophagy in regulating the chemosensitivity of HCC ce...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.08.039
更新日期：2017-11-28 00:00:00
abstract：:We investigated the effect of HMGB2 on the stability of p53 protein in HeLa cells. Overexpression of HMGB2 led to accumulation of the p53 protein, whereas HMGB2 knockdown with siRNA resulted in a substantial decrease in the p53 protein level. The HMGB2-dependent increase of p53 stability was specific for HPV-positive ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.11.015
更新日期：2010-06-01 00:00:00
abstract：:As the frequent emergency of resistant tumor cells during treatment, the development of new agents with new modes of action attracts a great deal of interest. Polybia-MPI was a short cationic alpha-helical amphiphilic peptide that has selective toxicity toward cancer cells but no hemolytic activity. Its target selecti...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.12.027
更新日期：2009-06-08 00:00:00
abstract：:Our earlier studies have shown that simultaneous inhibition of glycolysis and pentose phosphate pathway using 2-deoxy-d-glucose (2-DG, an inhibitor of glycolysis) and 6-aminonicotinamide (6-AN, an inhibitor of pentose phosphate pathway) lead to metabolic oxidative stress (MOS), resulting in radiosensitization in malig...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.02.021
更新日期：2010-09-28 00:00:00
abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.04.017
更新日期：2009-11-01 00:00:00
abstract：:Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.09.020
更新日期：2017-01-01 00:00:00
abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.05.012
更新日期：2016-08-10 00:00:00
abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.03.014
更新日期：2004-08-10 00:00:00
