Abstract：
:Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulence factors. The strongest candidates are genes within the cag (cytotoxin-associated antigen) pathogenicity island, including the gene encoding the CagA protein, as well as polymorphic variation in the VacA vacuolating exotoxin and the blood group antigen binding adhesin BabA. Improved understanding of the pathogenesis of H. pylori-associated gastric cancer may improve risk stratification for prevention and therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wen S,Moss SFdoi
10.1016/j.canlet.2008.11.016subject
Has Abstractpub_date
2009-09-08 00:00:00pages
1-8issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00909-9journal_volume
282pub_type
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