Abstract:
:The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed beta-catenin-mediated transcriptional activity.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zhang Y,Huang S,Dong W,Li L,Feng Y,Pan L,Han Z,Wang X,Ren G,Su D,Huang B,Lu Jdoi
10.1016/j.canlet.2008.11.014subject
Has Abstractpub_date
2009-05-08 00:00:00pages
29-37issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00893-8journal_volume
277pub_type
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