Abstract:
:HER2 positive breast cancers have been shown to have a greater propensity to metastasise to the brain. This may be due to several reasons, including the creation of a "sanctuary-site" for tumour in the brain following trastuzumab therapy. Elucidating the mechanism of this phenomenon may aid the prevention or intervention and treatment of such metastases, but research is limited by the deficiency and diminished access of CNS tissue. However, CNS penetrable HER2 receptor antagonists such as lapatinib and intrathecal administration of trastuzumab might benefit patients, and are worthy of further investigation. New avenues of molecular approach have focused on manipulating signal transduction system involved in HER2 function. The importance of systemic therapies and those targeted to metastatic lesions is emphasised and evaluated here.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Patil A,Sherbet GVdoi
10.1016/j.canlet.2014.12.026subject
Has Abstractpub_date
2015-03-28 00:00:00pages
93-99issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00781-2journal_volume
358pub_type
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