Abstract:
:Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlorophyllin. Polycyclic aromatic compounds, including heterocyclic amines, polycyclic aromatic hydrocarbons, aromatic amines and aromatic nitro compounds, were subject to inhibition, with a few exceptions. The results support the view that chlorophyllin traps carcinogens by forming complexes, thereby inhibiting the absorption of these compounds from the digestive tract. Consistent with this mechanism, Sepharose-supported chlorophyllin in the feed inhibited the Trp-P-2-induced wing spot formation, while Sepharose itself was ineffective.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu Hdoi
10.1016/0304-3835(94)90313-1subject
Has Abstractpub_date
1994-08-15 00:00:00pages
157-64issue
1-2eissn
0304-3835issn
1872-7980pii
0304-3835(94)90313-1journal_volume
83pub_type
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