Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila.

Abstract:

:Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlorophyllin. Polycyclic aromatic compounds, including heterocyclic amines, polycyclic aromatic hydrocarbons, aromatic amines and aromatic nitro compounds, were subject to inhibition, with a few exceptions. The results support the view that chlorophyllin traps carcinogens by forming complexes, thereby inhibiting the absorption of these compounds from the digestive tract. Consistent with this mechanism, Sepharose-supported chlorophyllin in the feed inhibited the Trp-P-2-induced wing spot formation, while Sepharose itself was ineffective.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu H

doi

10.1016/0304-3835(94)90313-1

subject

Has Abstract

pub_date

1994-08-15 00:00:00

pages

157-64

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(94)90313-1

journal_volume

83

pub_type

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