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Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells.

Abstract：

:Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines. Gel shift assay showed that induced c-Jun has specific DNA binding activity. Transient transfections demonstrated that c-Jun repressed prostate-specific antigen promoter activity and transcriptional activity of the AR promoter. These results support a mechanism in which overexpressed c-Jun mediates inhibitory effect on the function of AR. These polyphenols might potentially be useful in prostate cancer prevention.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Yuan H,Pan Y,Young CY

doi

10.1016/j.canlet.2004.04.003

keywords:

subject

Has Abstract

pub_date

2004-09-30 00:00:00

pages

155-63

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383504002800

journal_volume

213

pub_type

杂志文章

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