A novel class of antitumour agents. II. In vitro testing.

Abstract:

:Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose dependent within a certain range. With lower nontoxic doses, decreases in the mitotic and labelling indices were observed, and clotted mitotic figures occurred. The effects were essentially the same for all experimental cell types; chromosome alterations were not seen.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Emminger A,Kahmann E,Savage DS

doi

10.1016/s0304-3835(77)80032-3

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

273-8

issue

4-5

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(77)80032-3

journal_volume

2

pub_type

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