Abstract:
:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the tumor site using prostate-specific antigen-transfected CT26 cells. Three cycles of EGT/cytokines and i.t. DC inhibited tumor growth most effectively, but not superior to EGT/cytokines alone. However, the role of i.t. DC became significant when radiation was given after immunotherapy, which may have clinical implications on achieving better local control and prevention of systemic relapse.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang YS,Tsang YW,Chi CH,Chang CC,Chu RM,Chi KHdoi
10.1016/j.canlet.2008.02.063subject
Has Abstractpub_date
2008-08-08 00:00:00pages
275-85issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00173-0journal_volume
266pub_type
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