Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.

Abstract:

:We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating that COX-2 does not affect tumor initiation. Tumors in the COX-2 transgenic mice had higher levels of phosphorylated epidermal growth factor receptor and Akt compared to wild-type mice. Collectively, our data indicate that COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Al-Salihi MA,Terrece Pearman A,Doan T,Reichert EC,Rosenberg DW,Prescott SM,Stafforini DM,Topham MK

doi

10.1016/j.canlet.2008.08.012

subject

Has Abstract

pub_date

2009-01-18 00:00:00

pages

225-32

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(08)00618-6

journal_volume

273

pub_type

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