Polyamine levels in sarcoma-bearing rats in relation to growth and necrosis of the tumour cells.

abstract：:Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant found in plants, such as grapes, that studies suggest has cancer chemopreventive activity. We investigated the effects of resveratrol on DNA binding via esterification reactions with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP...

journal_title：Cancer letters

authors： Dubuisson JG,Dyess DL,Gaubatz JW

更新日期：2002-08-08 00:00:00

abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

journal_title：Cancer letters

authors： Li HW,Zhao W,Sarkar NH

更新日期：1994-05-16 00:00:00

abstract：:Many studies have shown that the activation of beta-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein-Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause ...

journal_title：Cancer letters

authors： Min HJ,Cho IR,Srisuttee R,Park EH,Cho DH,Ahn JH,Lee IS,Johnston RN,Oh S,Chung YH

更新日期：2009-04-18 00:00:00

abstract：:Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...

journal_title：Cancer letters

authors： Miyamoto N,Yamamoto H,Taniguchi H,Miyamoto C,Oki M,Adachi Y,Imai K,Shinomura Y

更新日期：2007-08-28 00:00:00

abstract：:We have developed an epithelial cell line derived from mouse liver which represents a spectrum of malignant progression. When inoculated into mice at low passage, the cells induced benign cysts; after extensive subcultures, the same line induced low grade adenocarcinomas. A variant of these cells with increased invasi...

journal_title：Cancer letters

authors： Dollbaum CM,Anderson LW,Smith HS

更新日期：1980-12-01 00:00:00

abstract：:Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...

journal_title：Cancer letters

authors： Chen Y,Gera L,Zhang S,Li X,Yang Y,Mamouni K,Wu AY,Liu H,Kucuk O,Wu D

更新日期：2019-04-01 00:00:00

abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...

journal_title：Cancer letters

authors： Lin LC,Gao AC,Lai CH,Hsieh JT,Lin H

更新日期：2017-04-10 00:00:00

abstract：:Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

journal_title：Cancer letters

authors： Snyder RD,Bhatt S

更新日期：1993-08-16 00:00:00

abstract：:In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response di...

journal_title：Cancer letters

authors： Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SM

更新日期：2001-07-26 00:00:00

abstract：:We analyzed TP53 codon 72 polymorphism, HPV DNA in 32 subjects with oesophageal cancer and 57 healthy subjects with normal oesophageal cytology from an area of China with a high prevalence for this cancer (Linxian County, Henan Province). The frequency of the proline allele (0.63) was significantly higher in the Chine...

journal_title：Cancer letters

authors： Peixoto Guimaraes D,Hsin Lu S,Snijders P,Wilmotte R,Herrero R,Lenoir G,Montesano R,Meijer CJ,Walboomers J,Hainaut P

更新日期：2001-01-26 00:00:00

abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

journal_title：Cancer letters

authors： Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

更新日期：2002-12-10 00:00:00

abstract：:Neuroblastoma is the most common extra-cranial solid tumor in children. Despite advances in the treatment of childhood cancer, outcomes for children with advanced-stage neuroblastoma remain poor. Here we reported that 2-methoxyestradiol (2-ME) inhibited the proliferation and induced apoptosis in human neuroblastoma SK...

journal_title：Cancer letters

authors： Zhang Q,Ma Y,Cheng YF,Li WJ,Zhang Z,Chen SY

更新日期：2011-12-27 00:00:00

abstract：:Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level ...

journal_title：Cancer letters

authors： King LC,Jackson M,Ball LM,Lewtas J

更新日期：1983-07-01 00:00:00

abstract：:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...

journal_title：Cancer letters

authors： Gatouillat G,Odot J,Balasse E,Nicolau C,Tosi PF,Hickman DT,López-Deber MP,Madoulet C

更新日期：2007-11-18 00:00:00

abstract：:The number of Krebs II tumour cells recovered from the ascitic fluid of mice fed for 8 days on a lactalbumin (La) control diet was about three times higher than that in animals fed a phytohaemagglutinin-containing (PHA) diet. Feeding a PHA diet for less than 8 days after tumour cell injection also led to a reduction i...

journal_title：Cancer letters

authors： Bardocz S,Grant G,Duguid TJ,Brown DS,Pusztai A,Pryme IF

更新日期：1997-12-16 00:00:00

abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...

journal_title：Cancer letters

authors： Rebuzzini P,Lisa A,Giulotto E,Mondello C

更新日期：2004-01-08 00:00:00

abstract：:Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...

journal_title：Cancer letters

authors： Ramesh G,Das UN

更新日期：1998-01-30 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:We investigated the effect of HMGB2 on the stability of p53 protein in HeLa cells. Overexpression of HMGB2 led to accumulation of the p53 protein, whereas HMGB2 knockdown with siRNA resulted in a substantial decrease in the p53 protein level. The HMGB2-dependent increase of p53 stability was specific for HPV-positive ...

journal_title：Cancer letters

authors： Lee D,Kwon JH,Kim EH,Kim ES,Choi KY

更新日期：2010-06-01 00:00:00

abstract：:Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out. Starting from the day of the ...

journal_title：Cancer letters

authors： Anisimov VN,Zabezhinski MA,Popovich IG,Zaripova EA,Musatov SA,Andre V,Vigreux C,Godard T,Sichel F

更新日期：2000-08-11 00:00:00

abstract：:Hypoxia-inducible factor 1 alpha (HIF-1 alpha) that regulates genes involved in response to hypoxia and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell growth factor (VEGF). The aim of this study was to examine the expression of HIF-1 alpha and VEGF gene expressions and their relat...

journal_title：Cancer letters

authors： Nakayama K,Kanzaki A,Hata K,Katabuchi H,Okamura H,Miyazaki K,Fukumoto M,Takebayashi Y

更新日期：2002-02-25 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lnc...

journal_title：Cancer letters

authors： Yao Y,Ma J,Xue Y,Wang P,Li Z,Liu J,Chen L,Xi Z,Teng H,Wang Z,Li Z,Liu Y

更新日期：2015-04-01 00:00:00

abstract：:Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upre...

journal_title：Cancer letters

authors： Du H,Bay BH,Mahendran R,Olivo M

更新日期：2006-04-28 00:00:00

abstract：:Human kinome/phosphatome screen identified CAMK2N1 genes suppressing the development of human hepatocellular carcinoma (HCC). CAMK2N1 downregulation was found in 47% HCCs and associated with poor prognosis. The downregulation was mainly attributed to its genome deletion (28.4%) and DNA hypermethylation of its promoter...

journal_title：Cancer letters

authors： Peng JM,Tseng RH,Shih TC,Hsieh SY

更新日期：2021-01-28 00:00:00

abstract：:Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistan...

journal_title：Cancer letters

authors： Bockstahler LE,Lytle CD,Lubiniecki AS,Cantwell JM,Galleshaw JA

更新日期：1982-11-01 00:00:00

abstract：:One of the 2 main components of the commercially available carcinogenic aristolochic acid (AA) was isolated, the other was enriched. Three different aristolochic acid samples (AAI 99% pure; AAI 65% + AAII 35%; AAI 32% + AAII 68%) were assayed for mutagenic activity in Salmonella typhimurium TA1537, TA100 and TA100 NR ...

journal_title：Cancer letters

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1984-05-01 00:00:00

abstract：:The preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737-740), also inhibits the activities of direct- and indirec...

journal_title：Cancer letters

authors： Chernomorsky S,Rancourt R,Virdi K,Segelman A,Poretz RD

更新日期：1997-12-09 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common neoplasms and a leading cause of death related to cancer worldwide. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent autosomal dominant predisposition to the development of CRC, accounting for approximately 2.5% of the total CRC burden in Spain. G...

journal_title：Cancer letters

authors： Castellví-Bel S,Castells A,Strunk M,Ferrández A,Piazuelo E,Milà M,Piñol V,Rodríguez-Moranta F,Andreu M,Lanas A,Piqué JM,Gastrointestinal Oncology Group of the Spanish Gastroenterological Association.

更新日期：2005-07-08 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...

journal_title：Cancer letters

authors： Lockshin A,Giovanella BC,Kozielski T,Stehlin JS Jr

更新日期：1984-09-01 00:00:00