Abstract：
:In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response did not reach statistical significance. Tumor incidence was significantly inhibited to 20% in the animals that received melatonin and 9cRA on alternating days. Latency to tumor onset was prolonged in animals receiving either of the combination treatments compared with controls, and tumor multiplicity was also significantly decreased.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Teplitzky SR,Kiefer TL,Cheng Q,Dwivedi PD,Moroz K,Myers L,Anderson MB,Collins A,Dai J,Yuan L,Spriggs LL,Blask DE,Hill SMdoi
10.1016/s0304-3835(01)00548-1keywords:
subject
Has Abstractpub_date
2001-07-26 00:00:00pages
155-63issue
2eissn
0304-3835issn
1872-7980pii
S0304383501005481journal_volume
168pub_type
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