Abstract:
:The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the considerable formation of nitroso compounds was observed for ethambutol, cinnarizine and pyridinol carbamate. The reaction product of pyridinol carbamate and nitrite was remarkably mutagenic to Salmonella typhimurium TA100 in the absence of S-9 mix. Under conditions presumed to resemble those in the stomach after ingestion of a therapeutic dose of the drug, the formation of nitroso compounds was observed for ethambutol and significant mutagenicity was detected in the reaction product of pyridinol carbamate.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Takeda Y,Kanaya Hdoi
10.1016/0304-3835(82)90075-1subject
Has Abstractpub_date
1982-01-01 00:00:00pages
53-9issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(82)90075-1journal_volume
15pub_type
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