Abstract:
:The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth and induce caspase-dependent apoptosis concentration-dependently, with dihydrotanshinone being the most potent. All four tanshinones were found to induce ROS generation, but only dihydrotanshinone can induce activation of p38 MAPK. The p38 MAPK activation by dihydrotanshinone was inhibited by N-acetyl cysteine pretreatment. It is thus concluded that ROS-mediated p38 MAPK activation plays a vital role in dihydrotanshinone-induced apoptosis in HepG2 cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lee WY,Liu KW,Yeung JHdoi
10.1016/j.canlet.2009.04.040subject
Has Abstractpub_date
2009-11-18 00:00:00pages
46-57issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00322-Xjournal_volume
285pub_type
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