Abstract:
:EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fung C,Zhou P,Joyce S,Trent K,Yuan JM,Grandis JR,Weissfeld JL,Romkes M,Weeks DE,Egloff AMdoi
10.1016/j.canlet.2014.12.008subject
Has Abstractpub_date
2015-02-28 00:00:00pages
549-56issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00751-4journal_volume
357pub_type
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