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Nitrosoproline formation in control and antibiotic-treated rats given nitrate and proline.

Abstract：

:The role of the gastrointestinal microflora in the nitrate-dependent formation of nitrosoproline was assessed in control and antibiotic-treated rats. Urinary nitrosoproline excretion as an index of in vivo nitrosamine formation was shown to be unaffected by bacterial decontamination of the alimentary tract, and proceeded in the absence of detectable nitrate reductase activity in the intestinal contents. These observations suggest that the gut microflora are not required for the formation of nitrosamino acid from nitrate and proline.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Mallett AK,Rowland IR,Cottrell RC,Gangolli SD

doi

10.1016/s0304-3835(84)80050-6

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

231-5

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(84)80050-6

journal_volume

25

pub_type

杂志文章

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