Multi-microarray identifies lower AQP9 expression in adjuvant chemotherapy nonresponders with stage III colorectal cancer.

abstract：:Two human cell lines, one established from a colon carcinoma (SW480) and the other from its lymph node metastasis (SW620), were compared with respect to their migration capacity employing a three-dimensional collagen matrix and time-lapse video recording. Non-motile cells were characterized by a round shape, whereas m...

journal_title：Cancer letters

authors： Kubens BS,Zänker KS

更新日期：1998-09-11 00:00:00

abstract：:A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...

journal_title：Cancer letters

authors： Grosso LE,Pitot HC

更新日期：1984-02-01 00:00:00

abstract：:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A ampli...

journal_title：Cancer letters

authors： Bodvarsdottir SK,Hilmarsdottir H,Birgisdottir V,Steinarsdottir M,Jonasson JG,Eyfjord JE

更新日期：2007-04-08 00:00:00

abstract：:The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometria...

journal_title：Cancer letters

authors： Konopka B,Paszko Z,Janiec-Jankowska A,Goluda M

更新日期：2002-04-08 00:00:00

abstract：:Under most circumstances, hepatitis B virus (HBV) is noncytopathic. However, hepatocellular regeneration that accompanies each bout of hepatitis appears to be associated with increased integration of HBV DNA fragments expressing the virus encoded hepatitis B x antigen (HBxAg). Intrahepatic HBxAg staining correlates wi...

journal_title：Cancer letters

authors： Feitelson MA,Reis HM,Tufan NL,Sun B,Pan J,Lian Z

更新日期：2009-12-01 00:00:00

abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...

journal_title：Cancer letters

authors： Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KH

更新日期：1994-12-09 00:00:00

abstract：:Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...

journal_title：Cancer letters

authors： Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DN

更新日期：1996-12-20 00:00:00

abstract：:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...

journal_title：Cancer letters

authors： Denda A,Tsutsumi M,Tsujiuchi T,Eimoto H,Konishi Y,Sato S

更新日期：1989-04-01 00:00:00

abstract：:Aberrant crypt foci (ACF) have recently been identified as early putative preneoplastic lesions which appear in the colons of experimental animals treated with colon carcinogens. In a recent study the two heterocyclic amines, 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyr...

journal_title：Cancer letters

authors： Kristiansen E

更新日期：1996-12-20 00:00:00

abstract：:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...

journal_title：Cancer letters

authors： Jiang W,Fujii H,Matsumoto T,Ohtsuji N,Tsurumaru M,Hino O

更新日期：2007-04-08 00:00:00

abstract：:Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo...

journal_title：Cancer letters

authors： Feng X,Yu Y,He S,Cheng J,Gong Y,Zhang Z,Yang X,Xu B,Liu X,Li CY,Tian L,Huang Q

更新日期：2017-01-28 00:00:00

abstract：:SIRT2, a member of the sirtuin family, is involved in the regulation of a variety of physiological functions. In addition, SIRT2 has been studied in the context of pathological conditions including neurodegenerative diseases, metabolic syndrome, and cancer. The effect of SIRT2 on cancer cell growth depends on cancer t...

journal_title：Cancer letters

authors： Cheon MG,Kim W,Choi M,Kim JE

更新日期：2015-01-28 00:00:00

abstract：:Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...

journal_title：Cancer letters

authors： Liang C,Qin Y,Zhang B,Ji S,Shi S,Xu W,Liu J,Xiang J,Liang D,Hu Q,Ni Q,Yu X,Xu J

更新日期：2017-03-01 00:00:00

abstract：:Osteosarcoma is the most common osteogenic malignant tumor characterized by a high level of malignancy, relapse, metastasis and poor prognosis. S100A4 has been implicated in the proliferation, cell cycle progression, and metastasis of many malignant tumors, although the roles of S100A4 in osteosarcoma have not been do...

journal_title：Cancer letters

authors： Ma X,Yang Y,Wang Y,An G,Lv G

更新日期：2010-12-28 00:00:00

abstract：:A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis ...

journal_title：Cancer letters

authors： Hanausek-Walaszek M,Del Rio M,Adams AK

更新日期：1989-12-01 00:00:00

abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...

journal_title：Cancer letters

authors： Poletto L,Morini JC

更新日期：1990-03-01 00:00:00

abstract：:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...

journal_title：Cancer letters

authors： Kuroda Y,Tsukino H,Nakao H,Imai H,Katoh T

更新日期：2003-01-10 00:00:00

abstract：:Fludarabine phosphate is a synthetic analog of beta-arabinofuranosyl adenine (beta-ara-A), an anti-viral agent. Since beta-ara-A has been shown to be an effective inhibitor of potentially lethal damage (PLD) repair in cell culture system but ineffective in in vivo tumors, we carried out experiments to determine whethe...

journal_title：Cancer letters

authors： Kim JH,Alfieri AA,Kim SH,Fuks Z

更新日期：1986-04-01 00:00:00

abstract：:Carcinogenic studies were performed on the skin of inbred male Lister rats using 7,12-dimethylbenz[alpha]anthracene (DMBA) in low doses (2.5 mg and 5.0 mg), followed by promotion with croton oil (CO) in one half of the animals. The clinically observed tumour rate did not differ after the two carcinogen doses and was p...

journal_title：Cancer letters

authors： Spaun E,Arffmann E

更新日期：1992-08-14 00:00:00

abstract：:The mesenchymal (MES) subtype of glioblastoma (GBM) indicated a more malignant phenotype and worse prognosis compared with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided an approach for clinical intervention. However, few miRNAs have been identified to participate...

journal_title：Cancer letters

authors： Yang F,Liu X,Liu Y,Liu Y,Zhang C,Wang Z,Jiang T,Wang Y

更新日期：2017-06-28 00:00:00

abstract：:Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibi...

journal_title：Cancer letters

authors： Bastian P,Balcarek A,Altanis C,Strell C,Niggemann B,Zaenker KS,Entschladen F

更新日期：2009-02-18 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP), which hydrolyzes type I collagen and activates MMP-2, are deeply involved in angiogenesis as well as in tumor cell invasion and metastasis. We previously screened a number of natural and synthetic compounds to obtain a specific inhibitor of MT1-MMP and observed that ...

journal_title：Cancer letters

authors： Yamakawa S,Asai T,Uchida T,Matsukawa M,Akizawa T,Oku N

更新日期：2004-07-08 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...

journal_title：Cancer letters

authors： Choo MK,Sakurai H,Koizumi K,Saiki I

更新日期：2005-12-08 00:00:00

abstract：:The effect of vitamin A (retinyl acetate) on lung tumor development in strain A mice exposed to radiation was assessed. Four groups of 75 mice were utilized. Two groups were fed a low vitamin A diet (less than 100 IU/100 g diet) and the other 2 were fed a high vitamin A diet (800 IU/100 g diet). After 2 weeks one grou...

journal_title：Cancer letters

authors： Mian TA,Theiss JC,Gesell TF

更新日期：1984-02-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

journal_title：Cancer letters

authors： Shen C,Yang C,Xia B,You M

更新日期：2021-03-01 00:00:00

abstract：:Rafoxanide is used in veterinary medicine for the treatment of fascioliasis. We previously repositioned the drug as the inhibitor of B-Raf V600E, but its anti-tumor effect in human cancer has never been reported. In this study, we investigated the effects of rafoxanide in multiple myeloma (MM) in vitro and in vivo. We...

journal_title：Cancer letters

authors： Xiao W,Xu Z,Chang S,Li B,Yu D,Wu H,Xie Y,Wang Y,Xie B,Sun X,Kong Y,Lan X,Bu W,Chen G,Gao L,Wu X,Shi J,Zhu W

更新日期：2019-03-01 00:00:00

abstract：:Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...

journal_title：Cancer letters

authors： Nakagawara A,Ohira M

更新日期：2004-02-20 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin. ...

journal_title：Cancer letters

authors： Schwartz HS

更新日期：1983-08-01 00:00:00