Abstract:
:Fludarabine phosphate is a synthetic analog of beta-arabinofuranosyl adenine (beta-ara-A), an anti-viral agent. Since beta-ara-A has been shown to be an effective inhibitor of potentially lethal damage (PLD) repair in cell culture system but ineffective in in vivo tumors, we carried out experiments to determine whether fludarabine phosphate which is not inactivated by adenosine deaminase potentiates the radiation effects on in vivo murine tumor. The combined effects of single acute fludarabine phosphate (600 mg/kg) and single dose of X-irradiation (20 Gy) on Meth-A fibrosarcomas in BALB/c mice produced more than 90% tumor control, while the radiation alone resulted in less than 10% tumor control. The radiosensitizing effect by fludarabine phosphate was higher when the drug was administered immediately prior to X-irradiation. The dose modifying factor of fludarabine phosphate is estimated to be 1.6 at 400 mg/kg. Experiments with fractionated irradiation and fludarabine phosphate similarly showed a high rate of tumor control. The present study suggests that inhibitors of PLD repair including several antiviral agents may have potential utility in the treatment of some radioresistant human tumors by radiotherapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kim JH,Alfieri AA,Kim SH,Fuks Zdoi
10.1016/0304-3835(86)90168-0subject
Has Abstractpub_date
1986-04-01 00:00:00pages
69-76issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(86)90168-0journal_volume
31pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00844-8
更新日期:2002-04-25 00:00:00
abstract::Many of the polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene (B[a]P), benzanthracene (BA), 3-methylcholanthrene (3-MC)) are not only carcinogenic, but also induce AHH in human tissues. Recently, chrysene has been implicated as an etiologic determinant of chemical carcinogenesis. Here we describe the ability of c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80059-2
更新日期:1979-10-01 00:00:00
abstract::Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.10.005
更新日期:2021-01-01 00:00:00
abstract::ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.01.006
更新日期:2019-04-10 00:00:00
abstract::The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.01.002
更新日期:2020-04-01 00:00:00
abstract::MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.09.022
更新日期:2009-02-18 00:00:00
abstract::Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovir...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.03.009
更新日期:2017-06-28 00:00:00
abstract::Benzo[a]pyrene (B[a]P) metabolism and macromolecular binding have been studied in explants from 4 tissues, bladder, skin, bronchus and esophagus from 8 donors sampled within 4 h after death. Explants were incubated with [3H]benzo[a]pyrene for 24 h, then the metabolites extracted and analyzed by high-pressure liquid ch...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90112-x
更新日期:1983-02-01 00:00:00
abstract::Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lnc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.051
更新日期:2015-04-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.03.017
更新日期:2007-09-08 00:00:00
abstract::The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.03.060
更新日期:2006-03-28 00:00:00
abstract::In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00406-7
更新日期:2000-07-03 00:00:00
abstract::The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90154-5
更新日期:1985-11-01 00:00:00
abstract::The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03836-l
更新日期:1995-07-20 00:00:00
abstract::Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.06.038
更新日期:2005-11-18 00:00:00
abstract::Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.08.008
更新日期:2010-12-28 00:00:00
abstract::Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accomp...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.11.036
更新日期:2012-05-01 00:00:00
abstract::RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.08.024
更新日期:2013-07-01 00:00:00
abstract::The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.03.029
更新日期:2020-07-28 00:00:00
abstract::Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized end...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.12.021
更新日期:2013-05-01 00:00:00
abstract::In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00870-9
更新日期:2002-06-28 00:00:00
abstract::Conditioned medium from a series of human breast cancer cell lines representing the phenotypes of estrogen dependence ZR-75-1, MCF-7), tamoxifen resistance (Z(+)-75-9a1, LY2) and estrogen independence (ZR-PR-Lt) contained four detectable insulin-like growth factor binding proteins (IGFBPs) of MW 24, 34, 44 and 70 kDa....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04104-4
更新日期:1996-02-06 00:00:00
abstract::Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.07.031
更新日期:2017-10-28 00:00:00
abstract::Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90086-1
更新日期:1983-11-01 00:00:00
abstract::Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiati...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.12.008
更新日期:2020-03-01 00:00:00
abstract::In a comparative experimental study, excisions of a transplanted Lewis lung carcinoma in BDF1 mice were performed by means of the CO2 laser and conventional methods, namely common scalpel and diathermy. The results showed a significant reduction in tumor recurrence and animal mortality rates (27.5% vs. 75% and 45%) af...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(76)80009-2
更新日期:1976-09-01 00:00:00
abstract::Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.05.015
更新日期:2004-11-08 00:00:00
abstract::Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.11.003
更新日期:2012-03-28 00:00:00
abstract::The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90093-4
更新日期:1984-07-01 00:00:00
abstract::Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00061-0
更新日期:1999-06-01 00:00:00