Abstract:
:In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and fumonisin-B1, which has been known as one of mycotoxins produced by Fusarium monifliforme, as a promoter. Further, EG-1 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumor using 4-nitroquinoline-N-oxide (4-NQO) as an initiator and glycerol as a promoter.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Takasaki M,Konoshima T,Etoh H,Pal Singh I,Tokuda H,Nishino Hdoi
10.1016/s0304-3835(00)00406-7keywords:
subject
Has Abstractpub_date
2000-07-03 00:00:00pages
61-5issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(00)00406-7journal_volume
155pub_type
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