Cells of origin and tumor-initiating cells for nonmelanoma skin cancers.

Abstract:

:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these mutations do not lead to skin cancer. One explanation is that most genetic hits are sustained by mature or transit cells with limited proliferative capacity and only stem cells that acquire genetic alterations have the potential to propagate a frank tumor. In this mini-review we will discuss recent studies that provide some of the first genetic evidence to support a stem cell origin for a number of skin cancer types.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Thieu K,Ruiz ME,Owens DM

doi

10.1016/j.canlet.2012.05.008

subject

Has Abstract

pub_date

2013-09-10 00:00:00

pages

82-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(12)00290-X

journal_volume

338

pub_type

杂志文章,评审
  • Carcinogen-induced alteration in liver epidermal growth factor receptor distribution during the promotion stage of hepatocarcinogenesis in rat.

    abstract::Changes in hepatic membrane binding capacity for epidermal growth factor (EGF) were assessed during 2-acetylaminofluorine (2-AAF)-induced hepatocarcinogenesis. An overall decrease in membrane EGF binding levels was observed throughout the period of 2-AAF administration. Immunochemical studies indicated the decreases i...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(96)04524-7

    authors: DeCicco LA,Kong J,Ringer DP

    更新日期:1997-01-01 00:00:00

  • Effects of curcumin on the formation of benzo[a]pyrene derived DNA adducts in vitro.

    abstract::The effects of turmeric (T), curcumins (Cs), aqueous turmeric extract (ATE) and curcumin-free aqueous turmeric extract (CFATE) on the formation of [3H]benzo[a]pyrene ([3H]B(a)P)-derived DNA adducts was studied in vitro employing mouse liver S9. A dose-dependent decrease in binding of [3H]B(a)P metabolites to calf thym...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(95)03903-a

    authors: Deshpande SS,Maru GB

    更新日期:1995-09-04 00:00:00

  • Involvement of the polyamine pathway in breast cancer progression.

    abstract::These experiments were designed to test the role of the polyamine pathway in breast cancer progression utilizing an experimental system based on the development of ovary-independent rat mammary tumors and their sequential transplantation into syngeneic hosts. Three key enzymes involved in the PA biosynthetic/catabolic...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(95)03763-m

    authors: Manni A,Grove R,Kunselman S,Aldaz CM

    更新日期:1995-05-25 00:00:00

  • Epstein-Barr virus infection leads to partial phenotypic reversion of terminally differentiated malignant B cells.

    abstract::The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2009.04.025

    authors: Anastasiadou E,Vaeth S,Cuomo L,Boccellato F,Vincenti S,Cirone M,Presutti C,Junker S,Winberg G,Frati L,Wade PA,Faggioni A,Trivedi P

    更新日期:2009-11-01 00:00:00

  • Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity.

    abstract::Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma. Intratumoral hypoxia, i.e. reduced oxygen supply following uncontrolled proliferation of cancer...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2019.02.030

    authors: Ullmann P,Nurmik M,Schmitz M,Rodriguez F,Weiler J,Qureshi-Baig K,Felten P,Nazarov PV,Nicot N,Zuegel N,Haan S,Letellier E

    更新日期:2019-05-28 00:00:00

  • Serum cholesterol and 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis.

    abstract::Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet wi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(81)90154-3

    authors: Klurfeld DM,Kritchevsky D

    更新日期:1981-12-01 00:00:00

  • Synergistic antitumor effect of adenovirus-mediated hING4 gene therapy and (125)I radiation therapy on pancreatic cancer.

    abstract::Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.11.003

    authors: Zhao Y,Su C,Zhai H,Tian Y,Sheng W,Miao J,Yang J

    更新日期:2012-03-28 00:00:00

  • Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes.

    abstract::Mantle cell lymphoma (MCL) is an aggressive and incurable mature B cell neoplasm. The current treatments are based on chemotherapeutics and new class of drugs (e.g. Ibrutinib(®)), which in most cases ends with tumor resistance and relapse. Therefore, further development of novel therapeutic modalities is needed. Exoso...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2015.04.026

    authors: Hazan-Halevy I,Rosenblum D,Weinstein S,Bairey O,Raanani P,Peer D

    更新日期:2015-08-01 00:00:00

  • Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells.

    abstract::CD271, known as a neurotrophin receptor, is expressed in various cancers such as hypopharyngeal cancer (HPC) and melanoma. We recently reported that CD271 is a cancer-stem-cell biomarker of HPC, and that its expression is essential for cancer-cell proliferation and is correlated with a poor prognosis in this disease. ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2019.07.011

    authors: Morita S,Mochizuki M,Wada K,Shibuya R,Nakamura M,Yamaguchi K,Yamazaki T,Imai T,Asada Y,Matsuura K,Sugamura K,Katori Y,Satoh K,Tamai K

    更新日期:2019-10-01 00:00:00

  • Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene.

    abstract::Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00095-0

    authors: Mitsumori K,Yasuhara K,Mori I,Hayashi S,Shimo T,Onodera H,Nomura T,Hayashi Y

    更新日期:1998-07-17 00:00:00

  • Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages.

    abstract::Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.01.005

    authors: Wang D,Wang X,Si M,Yang J,Sun S,Wu H,Cui S,Qu X,Yu X

    更新日期:2020-04-01 00:00:00

  • Modulation of cellular phosphoprotein profiles in transformation and redifferentiation of murine AKR embryonic fibroblastic cells.

    abstract::Cellular phosphoprotein profiles from normal mouse embryonic fibroblast AKR-2B cells were compared to those of their permanently, chemically transformed malignant counterparts AKR-MCA cells, and AKR-2B cells reversibly transformed by transforming growth factor (AKR-TGF). Similar 32P-phosphorylation profiles were obser...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(85)90153-3

    authors: Chakrabarty S,Brattain MG

    更新日期:1985-11-01 00:00:00

  • Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer.

    abstract::This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mouse prostates due to ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2019.01.035

    authors: Nikhil K,Chang L,Viccaro K,Jacobsen M,McGuire C,Satapathy SR,Tandiary M,Broman MM,Cresswell G,He YJ,Sandusky GE,Ratliff TL,Chowdhury D,Shah K

    更新日期:2019-04-28 00:00:00

  • Promoting effects of unilateral ureteric ligation on two-stage urinary bladder carcinogenesis in rats.

    abstract::The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(84)90093-4

    authors: Miyata Y,Fukushima S,Imaida K,Ito N

    更新日期:1984-07-01 00:00:00

  • Synergistic cytotoxic effect of human recombinant tumor necrosis factor alpha combined with dihydroambazone.

    abstract::Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S)....

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(90)90032-s

    authors: Baumgart J,Gase K,Schulze W,Suehnel J,Gutsche W,Behnke D

    更新日期:1990-11-05 00:00:00

  • IGFBP2 promotes salivary adenoid cystic carcinoma metastasis by activating the NF-κB/ZEB1 signaling pathway.

    abstract::Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IG...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2018.06.008

    authors: Yao X,Wang Y,Duan Y,Zhang Q,Li P,Jin R,Tao Y,Zhang W,Wang X,Jing C,Zhou X

    更新日期:2018-09-28 00:00:00

  • Unsaturated fatty acids bind Myc-Max transcription factor and inhibit Myc-Max-DNA complex formation.

    abstract::Oncoprotein Myc, hetero-dimerized with Max through a b/HLH/Zip region, is a transcription factor that governs important cellular processes such as cell cycle entry, proliferation and differentiation. We found that linoleic acid, isolated from Pollen Typhae, and other unsaturated fatty acids have strong inhibitory effe...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(02)00455-x

    authors: Chung S,Park S,Yang CH

    更新日期:2002-12-15 00:00:00

  • Blocking exposed PD-L1 elicited by nanosecond pulsed electric field reverses dysfunction of CD8+ T cells in liver cancer.

    abstract::As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatme...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.09.015

    authors: Qian J,Chen T,Wu Q,Zhou L,Zhou W,Wu L,Wang S,Lu J,Wang W,Li D,Xie H,Su R,Guo D,Liu Z,He N,Yin S,Zheng S

    更新日期:2020-12-28 00:00:00

  • Photodynamic inactivation of cancer cells in vitro. Effect of irradiation temperature and dose fractionation.

    abstract::Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(79)80090-7

    authors: Moan J,Christensen T

    更新日期:1979-05-01 00:00:00

  • Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.

    abstract::Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized end...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2012.12.021

    authors: Goto H,Matsuda K,Srikoon P,Kariya R,Hattori S,Taura M,Katano H,Okada S

    更新日期:2013-05-01 00:00:00

  • Increased expression of sialyl Lewis(x) antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer.

    abstract::Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with nega...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00705-4

    authors: Nakagoe T,Fukushima K,Sawai T,Tsuji T,Jibiki Ma,Nanashima A,Tanaka K,Yamaguchi H,Yasutake T,Ayabe H,Arisawa K,Ishikawa H

    更新日期:2002-01-25 00:00:00

  • Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma.

    abstract::Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, GBM patients exhibit various levels of the elevated expression of...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2012.12.005

    authors: Kohsaka S,Takahashi K,Wang L,Tanino M,Kimura T,Nishihara H,Tanaka S

    更新日期:2013-04-30 00:00:00

  • Epidemiology of lung cancer and lung cancer screening programs in China and the United States.

    abstract::Lung cancer is a heterogeneous disease that is impacted by environmental exposures and by constitutional genetic or epigenetic susceptibilities to disease development and progression. The United States and China have distinct and diverse populations and geographic environmental exposures that contribute to unique patt...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2019.10.009

    authors: Yang D,Liu Y,Bai C,Wang X,Powell CA

    更新日期:2020-01-01 00:00:00

  • Cyclic nucleotide concentrations in 1,2-dimethylhydrazine induced rat colon adenocarcinoma.

    abstract::The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(78)93192-0

    authors: Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

    更新日期:1978-01-01 00:00:00

  • Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

    abstract::Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2011.06.038

    authors: Balassiano K,Lima S,Jenab M,Overvad K,Tjonneland A,Boutron-Ruault MC,Clavel-Chapelon F,Canzian F,Kaaks R,Boeing H,Meidtner K,Trichopoulou A,Laglou P,Vineis P,Panico S,Palli D,Grioni S,Tumino R,Lund E,Bueno-de-Mesqui

    更新日期:2011-12-01 00:00:00

  • Melatonin inhibition of MCF-7 human breast-cancer cells growth: influence of cell proliferation rate.

    abstract::We have studied whether the cell proliferation rate modifies the inhibitory actions of melatonin on MCF-7 cell growth. The proliferative rate of cells was altered by plating them at different densities (5 x 10(4) to 100 x 10(4) cells/dish) in media with low charcoal-stripped serum concentrations. In this way, populati...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(95)03811-a

    authors: Cos S,Sánchez-Barceló EJ

    更新日期:1995-07-13 00:00:00

  • Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.

    abstract::Carcinogenic and modification potential of 6-mercaptopurine (6-MP) was studied in a medium-term bioassay system for rat liver carcinogenesis. F344 male rats were initiated with a single dose (200 mg/kg body wt.) of diethylnitrosamine (DEN) i.p. and fed diets containing either 0.005% or 0.02% 6-MP with or without 0.05%...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90069-8

    authors: Amanuma T,Maruyama H,Tsujiuchi T,Tsutsumi M,Denda A,Konishi Y

    更新日期:1992-06-15 00:00:00

  • The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism.

    abstract::In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00870-9

    authors: Kaufmann R,Junker U,Junker K,Nuske K,Ranke C,Zieger M,Scheele J

    更新日期:2002-06-28 00:00:00

  • Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

    abstract::Myeloid lineage immune cells, such as macrophages and dendritic cells, play important roles in the induction of antitumor immunity during the initial stage of the cancer-immunity cycle, eliciting antitumor adaptive immunity by phagocytosing cancer cells and processing cancer-specific antigens, and then presenting thes...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2019.03.018

    authors: Park SY,Kim IS

    更新日期:2019-06-28 00:00:00

  • Matrilysin is associated with progression of colorectal tumor.

    abstract::Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matr...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(96)04336-4

    authors: Ishikawa T,Ichikawa Y,Mitsuhashi M,Momiyama N,Chishima T,Tanaka K,Yamaoka H,Miyazakic K,Nagashima Y,Akitaya T,Shimada H

    更新日期:1996-10-01 00:00:00