Abstract:
:Mangiferin, a naturally occurring glucosylxanthone, was assessed for its immunomodulatory potential. The phytochemical induced extensive in vitro proliferation of murine splenocytes and thymocytes at the doses of 5-40 micrograms ml-1. Suppression of the proliferative response of the cells was observed with higher doses of mangiferin. Mangiferin also activated the splenocytes of tumor hosts at early and late stages of tumor growth. The Phytohemagglutinin (PHA) and Con A unresponsive splenocytes of advanced tumor bearer proliferated extensively in response to mangiferin. Mangiferin when used with Con A produced additive stimulatory effect and induced heightened DNA synthesis of normal and advanced tumor bearers' splenocytes.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chattopadhyay U,Das S,Guha S,Ghosal Sdoi
10.1016/0304-3835(87)90114-5subject
Has Abstractpub_date
1987-11-01 00:00:00pages
293-9issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(87)90114-5journal_volume
37pub_type
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